MIR3917

Summary

MIR3917 (microRNA 3917, HGNC:38911) is a microRNA gene on chromosome 1p36.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500808 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38911
Approved symbol	MIR3917
Name	microRNA 3917
Location	1p36.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3917
Ensembl gene	ENSG00000283938
Ensembl biotype	miRNA
Entrez	100500808
RNAcentral	URS000075BB4E — ncRNA, 93 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580971

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580971 — 1 exons

Exon	Start	End
ENSE00002720896	25906362	25906454

Expression profiles

Bgee: expression breadth broad, 42 present calls, max score 86.28.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.7715 / max 88.6392, expressed in 1435 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
11120	5.7715	1435

Top tissues by expression

42 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	86.28	gold quality
lymph node	UBERON:0000029	82.71	gold quality
skeletal muscle tissue	UBERON:0001134	79.03	gold quality
monocyte	CL:0000576	74.32	gold quality
islet of Langerhans	UBERON:0000006	71.52	gold quality
muscle of leg	UBERON:0001383	71.22	gold quality
gastrocnemius	UBERON:0001388	69.94	gold quality
left testis	UBERON:0004533	69.49	gold quality
body of stomach	UBERON:0001161	69.22	gold quality
testis	UBERON:0000473	69.07	gold quality
endometrium	UBERON:0001295	68.86	gold quality
right atrium auricular region	UBERON:0006631	68.61	gold quality
tibial nerve	UBERON:0001323	68.35	gold quality
right testis	UBERON:0004534	67.97	gold quality
substantia nigra	UBERON:0002038	67.61	gold quality
blood	UBERON:0000178	67.04	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.92	gold quality
transverse colon	UBERON:0001157	66.65	gold quality
upper lobe of left lung	UBERON:0008952	65.86	gold quality
thoracic aorta	UBERON:0001515	65.23	gold quality
right frontal lobe	UBERON:0002810	64.68	gold quality
anterior cingulate cortex	UBERON:0009835	64.15	gold quality
thoracic mammary gland	UBERON:0005200	63.51	gold quality
right hemisphere of cerebellum	UBERON:0014890	63.40	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.31	gold quality
cerebellar hemisphere	UBERON:0002245	63.30	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.23	gold quality
tibial artery	UBERON:0007610	62.27	gold quality
pituitary gland	UBERON:0000007	61.84	gold quality
omental fat pad	UBERON:0010414	61.47	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• M2 macrophages-derived exosomal miR-3917 promotes the progression of lung cancer via targeting GRK6. (PMID:36261031)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.