MIR3918

Summary

MIR3918 (microRNA 3918, HGNC:38919) is a microRNA gene on chromosome 6q25.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500851 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38919
Approved symbol	MIR3918
Name	microRNA 3918
Location	6q25.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3918
Ensembl gene	ENSG00000265558
Ensembl biotype	miRNA
Entrez	100500851
RNAcentral	URS000075B9DC — miRNA, 93 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581555

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581555 — 1 exons

Exon	Start	End
ENSE00002728858	158764661	158764753

Expression profiles

Bgee: expression breadth broad, 58 present calls, max score 82.08.

Top tissues by expression

58 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	82.08	gold quality
body of stomach	UBERON:0001161	78.08	gold quality
duodenum	UBERON:0002114	75.24	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	74.57	gold quality
right lobe of thyroid gland	UBERON:0001119	73.98	gold quality
islet of Langerhans	UBERON:0000006	73.35	gold quality
endometrium	UBERON:0001295	72.65	gold quality
adult mammalian kidney	UBERON:0000082	71.66	gold quality
mucosa of stomach	UBERON:0001199	69.36	gold quality
body of uterus	UBERON:0009853	68.04	gold quality
vermiform appendix	UBERON:0001154	67.63	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.45	gold quality
omental fat pad	UBERON:0010414	66.05	gold quality
muscle of leg	UBERON:0001383	65.88	gold quality
gastrocnemius	UBERON:0001388	65.15	gold quality
right atrium auricular region	UBERON:0006631	64.52	gold quality
left adrenal gland	UBERON:0001234	64.14	gold quality
right ovary	UBERON:0002118	64.06	gold quality
spleen	UBERON:0002106	63.88	gold quality
body of pancreas	UBERON:0001150	63.19	gold quality
liver	UBERON:0002107	63.17	gold quality
caudate nucleus	UBERON:0001873	63.16	gold quality
muscle layer of sigmoid colon	UBERON:0035805	62.00	gold quality
prostate gland	UBERON:0002367	61.96	gold quality
adrenal gland	UBERON:0002369	61.80	gold quality
skin of leg	UBERON:0001511	61.34	gold quality
amygdala	UBERON:0001876	61.03	gold quality
myometrium	UBERON:0001296	60.23	gold quality
lower esophagus muscularis layer	UBERON:0035833	60.21	gold quality
esophagus mucosa	UBERON:0002469	60.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• MiR-3918 Inhibits Tumorigenesis of Glioma via Targeting EGFR to Regulate PI3K/AKT and ERK Pathways. (PMID:35023001)
• LncRNA ASB16-AS1 accelerates cellular process and chemoresistance of ovarian cancer cells by regulating GOLM1 expression via targeting miR-3918. (PMID:37429067)
• LncRNA FOXD3-AS1 Contributes to Glioblastoma Progression Via Sponging miR-3918 to Upregulate CCND1. (PMID:38497174)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.