MIR3919

Summary

MIR3919 (microRNA 3919, HGNC:38890) is a microRNA gene on chromosome 3q25.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500803 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38890
Approved symbol	MIR3919
Name	microRNA 3919
Location	3q25.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3919
Ensembl gene	ENSG00000263634
Ensembl biotype	miRNA
Entrez	100500803
RNAcentral	URS000075DBBA — ncRNA, 89 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583286

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583286 — 1 exons

Exon	Start	End
ENSE00002721009	159282646	159282734

Expression profiles

Bgee: expression breadth broad, 15 present calls, max score 77.14.

Top tissues by expression

15 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	77.14	gold quality
stomach	UBERON:0000945	71.50	gold quality
Ammon’s horn	UBERON:0001954	68.18	gold quality
corpus callosum	UBERON:0002336	68.18	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.77	gold quality
adenohypophysis	UBERON:0002196	66.29	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.64	gold quality
right atrium auricular region	UBERON:0006631	62.84	gold quality
hypothalamus	UBERON:0001898	62.79	gold quality
right frontal lobe	UBERON:0002810	61.34	gold quality
caudate nucleus	UBERON:0001873	59.50	gold quality
pituitary gland	UBERON:0000007	59.16	gold quality
anterior cingulate cortex	UBERON:0009835	56.82	gold quality
prostate gland	UBERON:0002367	56.07	gold quality
left testis	UBERON:0004533	38.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.