MIR3920

Summary

MIR3920 (microRNA 3920, HGNC:38974) is a microRNA gene on chromosome 11q22.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500823 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38974
Approved symbol	MIR3920
Name	microRNA 3920
Location	11q22.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3920
Ensembl gene	ENSG00000263885
Ensembl biotype	miRNA
Entrez	100500823
RNAcentral	URS000075C520 — miRNA, 86 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581751

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581751 — 1 exons

Exon	Start	End
ENSE00002714899	101519820	101519905

Expression profiles

Bgee: expression breadth broad, 40 present calls, max score 76.97.

Top tissues by expression

40 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	76.97	gold quality
gastrocnemius	UBERON:0001388	76.49	gold quality
endometrium	UBERON:0001295	76.15	gold quality
lung	UBERON:0002048	75.39	gold quality
blood	UBERON:0000178	74.40	gold quality
monocyte	CL:0000576	72.37	gold quality
heart left ventricle	UBERON:0002084	70.59	gold quality
myometrium	UBERON:0001296	69.86	gold quality
tibial artery	UBERON:0007610	69.07	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.58	gold quality
kidney	UBERON:0002113	68.28	gold quality
left coronary artery	UBERON:0001626	67.44	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.44	gold quality
ascending aorta	UBERON:0001496	67.25	gold quality
left adrenal gland	UBERON:0001234	67.20	gold quality
lower esophagus	UBERON:0013473	67.05	gold quality
right coronary artery	UBERON:0001625	66.42	gold quality
intestine	UBERON:0000160	65.87	gold quality
left lobe of thyroid gland	UBERON:0001120	65.46	gold quality
body of uterus	UBERON:0009853	64.90	gold quality
adult mammalian kidney	UBERON:0000082	64.76	gold quality
transverse colon	UBERON:0001157	64.28	gold quality
right ovary	UBERON:0002118	64.01	gold quality
left ovary	UBERON:0002119	63.72	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.60	gold quality
vagina	UBERON:0000996	63.29	gold quality
tibial nerve	UBERON:0001323	63.15	gold quality
subcutaneous adipose tissue	UBERON:0002190	62.90	gold quality
right atrium auricular region	UBERON:0006631	62.19	gold quality
body of pancreas	UBERON:0001150	61.73	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.99

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.