MIR3921

Summary

MIR3921 (microRNA 3921, HGNC:38936) is a microRNA gene on chromosome 3q12.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500859 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38936
Approved symbol	MIR3921
Name	microRNA 3921
Location	3q12.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3921
Ensembl gene	ENSG00000264897
Ensembl biotype	miRNA
Entrez	100500859
RNAcentral	URS000075D620 — miRNA, 85 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577308

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577308 — 1 exons

Exon	Start	End
ENSE00002711573	99964314	99964398

Expression profiles

Bgee: expression breadth broad, 26 present calls, max score 86.44.

Top tissues by expression

26 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.44	gold quality
muscle of leg	UBERON:0001383	79.82	gold quality
blood	UBERON:0000178	76.70	gold quality
monocyte	CL:0000576	75.93	gold quality
right atrium auricular region	UBERON:0006631	74.09	gold quality
body of pancreas	UBERON:0001150	72.18	gold quality
calcaneal tendon	UBERON:0003701	72.09	gold quality
gastrocnemius	UBERON:0001388	71.80	gold quality
body of stomach	UBERON:0001161	70.92	gold quality
tibial artery	UBERON:0007610	68.74	gold quality
skin of abdomen	UBERON:0001416	64.39	gold quality
skin of leg	UBERON:0001511	64.38	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.95	gold quality
intestine	UBERON:0000160	62.96	gold quality
putamen	UBERON:0001874	61.83	gold quality
corpus callosum	UBERON:0002336	61.60	gold quality
cerebellar hemisphere	UBERON:0002245	61.34	gold quality
left ovary	UBERON:0002119	61.02	gold quality
left lobe of thyroid gland	UBERON:0001120	60.95	gold quality
Brodmann (1909) area 9	UBERON:0013540	60.83	gold quality
small intestine Peyer’s patch	UBERON:0003454	60.64	gold quality
right hemisphere of cerebellum	UBERON:0014890	60.28	gold quality
colon	UBERON:0001155	59.29	gold quality
right frontal lobe	UBERON:0002810	54.52	gold quality
prostate gland	UBERON:0002367	53.65	gold quality
left testis	UBERON:0004533	38.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.14

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.