MIR3922

Summary

MIR3922 (microRNA 3922, HGNC:38895) is a microRNA gene on chromosome 12q23.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500843 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38895
Approved symbol	MIR3922
Name	microRNA 3922
Location	12q23.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3922
Ensembl gene	ENSG00000264295
Ensembl biotype	miRNA
Entrez	100500843
RNAcentral	URS000075D152 — miRNA, 84 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585192

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585192 — 1 exons

Exon	Start	End
ENSE00002702260	104591633	104591716

Expression profiles

Bgee: expression breadth broad, 21 present calls, max score 78.46.

Top tissues by expression

21 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	78.46	gold quality
heart left ventricle	UBERON:0002084	77.64	gold quality
monocyte	CL:0000576	74.82	gold quality
gastrocnemius	UBERON:0001388	73.26	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.07	gold quality
liver	UBERON:0002107	68.65	gold quality
minor salivary gland	UBERON:0001830	68.33	gold quality
stomach	UBERON:0000945	67.81	gold quality
left adrenal gland	UBERON:0001234	67.78	gold quality
intestine	UBERON:0000160	67.49	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.02	gold quality
transverse colon	UBERON:0001157	65.53	gold quality
body of stomach	UBERON:0001161	63.09	gold quality
omental fat pad	UBERON:0010414	62.25	gold quality
small intestine Peyer’s patch	UBERON:0003454	58.56	gold quality
pituitary gland	UBERON:0000007	58.11	gold quality
esophagus mucosa	UBERON:0002469	54.89	gold quality
right frontal lobe	UBERON:0002810	54.88	gold quality
cerebellar hemisphere	UBERON:0002245	53.95	gold quality
corpus callosum	UBERON:0002336	52.34	gold quality
hypothalamus	UBERON:0001898	49.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.44

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• HOXC-AS3 is aberrantly overexpressed in breast cancers especially the HER2+ type. High expression of HOXC-AS3 has a relationship with poor clinical outcomes of breast cancer. HOXC-AS3 regulates cell invasion and migration both in vitro and in vivo. Results demonstrated that miR-3922-5p was a direct target of HOXC-AS3, and PPP1R1A was a target of miR-3922-5p in breast cancer. (PMID:31797701)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.