MIR3923

Summary

MIR3923 (microRNA 3923, HGNC:38978) is a microRNA gene on chromosome 3p12.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500877 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38978
Approved symbol	MIR3923
Name	microRNA 3923
Location	3p12.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3923
Ensembl gene	ENSG00000265193
Ensembl biotype	miRNA
Entrez	100500877
RNAcentral	URS000075D365 — miRNA, 83 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579521

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579521 — 1 exons

Exon	Start	End
ENSE00002686326	79507887	79507969

Expression profiles

Bgee: expression breadth broad, 13 present calls, max score 78.87.

Top tissues by expression

13 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	78.87	gold quality
fallopian tube	UBERON:0003889	71.78	gold quality
nucleus accumbens	UBERON:0001882	69.31	gold quality
left adrenal gland	UBERON:0001234	65.75	gold quality
left ovary	UBERON:0002119	64.82	gold quality
anterior cingulate cortex	UBERON:0009835	62.81	gold quality
hypothalamus	UBERON:0001898	62.37	gold quality
putamen	UBERON:0001874	60.35	gold quality
colon	UBERON:0001155	59.49	gold quality
prostate gland	UBERON:0002367	57.09	gold quality
pituitary gland	UBERON:0000007	56.02	gold quality
left testis	UBERON:0004533	42.41	gold quality
right testis	UBERON:0004534	39.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.