MIR3924

Summary

MIR3924 (microRNA 3924, HGNC:38984) is a microRNA gene on chromosome 10q21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500834 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38984
Approved symbol	MIR3924
Name	microRNA 3924
Location	10q21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3924
Ensembl gene	ENSG00000264747
Ensembl biotype	miRNA
Entrez	100500834
RNAcentral	URS000075D073 — miRNA, 81 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583084

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583084 — 1 exons

Exon	Start	End
ENSE00002691119	57304479	57304559

Expression profiles

Bgee: expression breadth tissue_specific, 9 present calls, max score 77.80.

Top tissues by expression

9 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stomach	UBERON:0000945	77.80	gold quality
heart	UBERON:0000948	73.66	gold quality
gastrocnemius	UBERON:0001388	71.46	gold quality
monocyte	CL:0000576	69.84	gold quality
left lobe of thyroid gland	UBERON:0001120	60.86	gold quality
thyroid gland	UBERON:0002046	60.09	gold quality
corpus callosum	UBERON:0002336	52.44	gold quality
testis	UBERON:0000473	42.24	gold quality
left testis	UBERON:0004533	36.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.