MIR3925

Summary

MIR3925 (microRNA 3925, HGNC:38996) is a microRNA gene on chromosome 6p21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500885 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38996
Approved symbol	MIR3925
Name	microRNA 3925
Location	6p21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3925
Ensembl gene	ENSG00000263894
Ensembl biotype	miRNA
Entrez	100500885
RNAcentral	URS000075CC9E — ncRNA, 77 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584674

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584674 — 1 exons

Exon	Start	End
ENSE00002694049	36622436	36622512

Expression profiles

Bgee: expression breadth broad, 44 present calls, max score 81.05.

Top tissues by expression

44 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	81.05	gold quality
granulocyte	CL:0000094	75.46	gold quality
islet of Langerhans	UBERON:0000006	75.19	gold quality
blood	UBERON:0000178	75.19	gold quality
gastrocnemius	UBERON:0001388	70.56	gold quality
lung	UBERON:0002048	70.21	gold quality
caudate nucleus	UBERON:0001873	68.63	gold quality
ascending aorta	UBERON:0001496	68.34	gold quality
cerebellar hemisphere	UBERON:0002245	68.13	gold quality
heart left ventricle	UBERON:0002084	67.99	gold quality
ovary	UBERON:0000992	67.83	gold quality
right lobe of thyroid gland	UBERON:0001119	67.38	gold quality
right coronary artery	UBERON:0001625	66.96	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.61	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.36	gold quality
right adrenal gland cortex	UBERON:0035827	66.24	gold quality
body of stomach	UBERON:0001161	66.16	gold quality
body of pancreas	UBERON:0001150	65.91	gold quality
omental fat pad	UBERON:0010414	65.52	gold quality
skin of leg	UBERON:0001511	65.07	gold quality
tibial artery	UBERON:0007610	64.71	gold quality
right hemisphere of cerebellum	UBERON:0014890	64.12	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.08	gold quality
adult mammalian kidney	UBERON:0000082	63.70	gold quality
minor salivary gland	UBERON:0001830	63.54	gold quality
brain	UBERON:0000955	62.79	gold quality
vagina	UBERON:0000996	62.66	gold quality
skin of abdomen	UBERON:0001416	62.55	gold quality
anterior cingulate cortex	UBERON:0009835	62.07	gold quality
spleen	UBERON:0002106	61.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.