MIR3926-1

Summary

MIR3926-1 (microRNA 3926-1, HGNC:38959) is a microRNA gene on chromosome 8p23.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500870 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38959
Approved symbol	MIR3926-1
Name	microRNA 3926-1
Location	8p23.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3926-1
Ensembl gene	ENSG00000266206
Ensembl biotype	miRNA
Entrez	100500870
RNAcentral	URS000075B286 — miRNA, 73 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578598

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578598 — 1 exons

Exon	Start	End
ENSE00002697807	12727232	12727304

Expression profiles

Bgee: expression breadth broad, 69 present calls, max score 73.17.

Top tissues by expression

69 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	73.17	gold quality
gastrocnemius	UBERON:0001388	72.29	gold quality
endometrium	UBERON:0001295	71.76	gold quality
right lobe of liver	UBERON:0001114	71.28	gold quality
skin of abdomen	UBERON:0001416	70.29	gold quality
right atrium auricular region	UBERON:0006631	69.86	gold quality
descending thoracic aorta	UBERON:0002345	69.63	gold quality
mucosa of stomach	UBERON:0001199	69.47	gold quality
tibial artery	UBERON:0007610	69.12	gold quality
body of pancreas	UBERON:0001150	69.10	gold quality
skin of leg	UBERON:0001511	68.44	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.09	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.63	gold quality
ectocervix	UBERON:0012249	67.62	gold quality
heart left ventricle	UBERON:0002084	67.59	gold quality
thoracic aorta	UBERON:0001515	67.54	gold quality
urinary bladder	UBERON:0001255	67.50	gold quality
ascending aorta	UBERON:0001496	67.21	gold quality
esophagus	UBERON:0001043	66.86	gold quality
fundus of stomach	UBERON:0001160	66.82	gold quality
body of stomach	UBERON:0001161	66.72	gold quality
left adrenal gland	UBERON:0001234	66.67	gold quality
left adrenal gland cortex	UBERON:0035825	66.60	gold quality
myometrium	UBERON:0001296	66.58	gold quality
left ovary	UBERON:0002119	66.58	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.24	gold quality
right adrenal gland	UBERON:0001233	66.02	gold quality
hypothalamus	UBERON:0001898	65.70	gold quality
omental fat pad	UBERON:0010414	65.62	gold quality
vagina	UBERON:0000996	65.47	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.19

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Low miR3926 expression is associated with the pathogenesis of rheumatoid arthritis. (PMID:30412746)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.