MIR3927

Summary

MIR3927 (microRNA 3927, HGNC:38901) is a microRNA gene on chromosome 9q31.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500898 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38901
Approved symbol	MIR3927
Name	microRNA 3927
Location	9q31.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3927
Ensembl gene	ENSG00000263861
Ensembl biotype	miRNA
Entrez	100500898
RNAcentral	URS000075A05C — miRNA, 71 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579313

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579313 — 1 exons

Exon	Start	End
ENSE00002710565	109511475	109511545

Expression profiles

Bgee: expression breadth broad, 14 present calls, max score 75.21.

Top tissues by expression

14 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	75.21	gold quality
right lobe of liver	UBERON:0001114	69.29	gold quality
blood	UBERON:0000178	67.23	gold quality
endometrium	UBERON:0001295	65.50	gold quality
skin of abdomen	UBERON:0001416	65.25	gold quality
esophagus mucosa	UBERON:0002469	64.84	gold quality
skin of leg	UBERON:0001511	64.42	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.37	gold quality
thoracic mammary gland	UBERON:0005200	64.18	gold quality
transverse colon	UBERON:0001157	62.50	gold quality
prostate gland	UBERON:0002367	61.33	gold quality
small intestine Peyer’s patch	UBERON:0003454	60.17	gold quality
vagina	UBERON:0000996	60.04	gold quality
left testis	UBERON:0004533	47.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.20

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.