MIR3928

Summary

MIR3928 (microRNA 3928, HGNC:38933) is a microRNA gene on chromosome 22q12.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500901 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38933
Approved symbol	MIR3928
Name	microRNA 3928
Location	22q12.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3928
Ensembl gene	ENSG00000264141
Ensembl biotype	miRNA
Entrez	100500901
RNAcentral	URS0000759DF9 — miRNA, 58 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583386

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583386 — 1 exons

Exon	Start	End
ENSE00002699481	31160062	31160119

Expression profiles

Bgee: expression breadth broad, 48 present calls, max score 82.92.

Top tissues by expression

48 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.92	gold quality
lymph node	UBERON:0000029	78.52	gold quality
blood	UBERON:0000178	73.64	gold quality
monocyte	CL:0000576	71.97	gold quality
tibial artery	UBERON:0007610	71.16	gold quality
body of stomach	UBERON:0001161	70.35	gold quality
right atrium auricular region	UBERON:0006631	70.33	gold quality
amygdala	UBERON:0001876	70.27	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.15	gold quality
body of pancreas	UBERON:0001150	69.81	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.32	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.07	gold quality
substantia nigra	UBERON:0002038	68.84	gold quality
putamen	UBERON:0001874	68.74	gold quality
granulocyte	CL:0000094	68.42	gold quality
pituitary gland	UBERON:0000007	67.90	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.83	gold quality
omental fat pad	UBERON:0010414	67.57	gold quality
caudate nucleus	UBERON:0001873	67.38	gold quality
ascending aorta	UBERON:0001496	67.33	gold quality
skin of abdomen	UBERON:0001416	67.01	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.99	gold quality
transverse colon	UBERON:0001157	66.88	gold quality
right frontal lobe	UBERON:0002810	66.59	gold quality
minor salivary gland	UBERON:0001830	66.53	gold quality
skin of leg	UBERON:0001511	66.45	gold quality
right hemisphere of cerebellum	UBERON:0014890	66.22	gold quality
cerebellar hemisphere	UBERON:0002245	66.14	gold quality
nucleus accumbens	UBERON:0001882	66.06	gold quality
esophagus mucosa	UBERON:0002469	65.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.29

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• MiR-3928 plays an important role in regulating the expression of Dicer. (PMID:22922797)
• High miR-3928 expression is significantly associated with squamous cell carcinoma of the lung. (PMID:30337605)
• Salivary miR-let-7a-5p and miR-3928 were significantly down regulated in saliva of head and neck squamous cell carcinoma patients, and have the potential to be novel non-invasive biomarkers for early detection and prognosis head and neck squamous cell carcinoma. (PMID:32208417)
• MicroRNA 3928 Suppresses Glioblastoma through Downregulation of Several Oncogenes and Upregulation of p53. (PMID:35409289)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.