MIR3934

Summary

MIR3934 (microRNA 3934, HGNC:38965) is a microRNA gene on chromosome 6p21.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500873 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38965
Approved symbol	MIR3934
Name	microRNA 3934
Location	6p21.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3934
Ensembl gene	ENSG00000266509
Ensembl biotype	miRNA
Entrez	100500873
RNAcentral	URS000075EA68 — miRNA, 107 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579806

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579806 — 1 exons

Exon	Start	End
ENSE00002717113	33698128	33698234

Expression profiles

Bgee: expression breadth broad, 29 present calls, max score 73.88.

Top tissues by expression

29 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	73.88	gold quality
blood	UBERON:0000178	69.78	gold quality
islet of Langerhans	UBERON:0000006	68.98	gold quality
left coronary artery	UBERON:0001626	66.44	gold quality
muscle of leg	UBERON:0001383	65.92	gold quality
gastrocnemius	UBERON:0001388	65.02	gold quality
tibial artery	UBERON:0007610	64.57	gold quality
body of pancreas	UBERON:0001150	62.89	gold quality
heart	UBERON:0000948	62.82	gold quality
omental fat pad	UBERON:0010414	61.06	gold quality
thoracic aorta	UBERON:0001515	60.84	gold quality
skin of leg	UBERON:0001511	60.67	gold quality
minor salivary gland	UBERON:0001830	59.76	gold quality
skin of abdomen	UBERON:0001416	58.67	gold quality
ascending aorta	UBERON:0001496	57.73	gold quality
subcutaneous adipose tissue	UBERON:0002190	55.20	gold quality
testis	UBERON:0000473	54.78	gold quality
stomach	UBERON:0000945	54.08	gold quality
lower esophagus muscularis layer	UBERON:0035833	53.95	gold quality
right atrium auricular region	UBERON:0006631	52.38	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	52.27	gold quality
lung	UBERON:0002048	49.84	gold quality
esophagus mucosa	UBERON:0002469	48.70	gold quality
tibial nerve	UBERON:0001323	48.27	gold quality
body of stomach	UBERON:0001161	47.18	gold quality
upper lobe of left lung	UBERON:0008952	46.64	gold quality
left ovary	UBERON:0002119	41.65	silver quality
body of uterus	UBERON:0009853	41.05	silver quality
right lung	UBERON:0002167	38.88	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Downregulation of miR-3934 in Peripheral Blood Mononuclear Cells of Asthmatic Patients and Its Potential Diagnostic Value. (PMID:33506046)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.