MIR3935

Summary

MIR3935 (microRNA 3935, HGNC:38918) is a microRNA gene on chromosome 16q13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500891 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38918
Approved symbol	MIR3935
Name	microRNA 3935
Location	16q13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3935
Ensembl gene	ENSG00000265281
Ensembl biotype	miRNA
Entrez	100500891
RNAcentral	URS000075E825 — ncRNA, 104 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583472

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583472 — 1 exons

Exon	Start	End
ENSE00002713595	56245520	56245623

Expression profiles

Bgee: expression breadth broad, 65 present calls, max score 98.28.

Top tissues by expression

65 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	98.28	gold quality
adrenal tissue	UBERON:0018303	86.26	gold quality
calcaneal tendon	UBERON:0003701	79.45	gold quality
lung	UBERON:0002048	76.38	gold quality
blood	UBERON:0000178	75.88	gold quality
adult mammalian kidney	UBERON:0000082	75.52	gold quality
gastrocnemius	UBERON:0001388	73.08	gold quality
amygdala	UBERON:0001876	73.04	gold quality
stomach	UBERON:0000945	72.80	gold quality
islet of Langerhans	UBERON:0000006	72.67	gold quality
kidney	UBERON:0002113	72.13	gold quality
right atrium auricular region	UBERON:0006631	71.67	gold quality
heart left ventricle	UBERON:0002084	71.27	gold quality
liver	UBERON:0002107	70.51	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.39	gold quality
intestine	UBERON:0000160	70.16	gold quality
tibial artery	UBERON:0007610	70.05	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.96	gold quality
body of stomach	UBERON:0001161	69.75	gold quality
colon	UBERON:0001155	69.65	gold quality
ascending aorta	UBERON:0001496	69.51	gold quality
Ammon’s horn	UBERON:0001954	69.33	gold quality
esophagus mucosa	UBERON:0002469	69.20	gold quality
right lobe of liver	UBERON:0001114	69.14	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.99	gold quality
anterior cingulate cortex	UBERON:0009835	68.61	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.55	gold quality
putamen	UBERON:0001874	68.53	gold quality
transverse colon	UBERON:0001157	68.35	gold quality
body of uterus	UBERON:0009853	68.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LINC00992 contributes to the oncogenic phenotypes in prostate cancer via targeting miR-3935 and augmenting GOLM1 expression. (PMID:32781986)
• MicroRNA-3935 promotes human trophoblast cell epithelial-mesenchymal transition through tumor necrosis factor receptor-associated factor 6/regulator of G protein signaling 2 axis. (PMID:34493304)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.