MIR3936

Summary

MIR3936 (microRNA 3936, HGNC:38947) is a microRNA gene on chromosome 5q31.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500865 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38947
Approved symbol	MIR3936
Name	microRNA 3936
Location	5q31.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3936
Ensembl gene	ENSG00000263597
Ensembl biotype	miRNA
Entrez	100500865
RNAcentral	URS000075A25E — miRNA, 110 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584304

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584304 — 1 exons

Exon	Start	End
ENSE00002707276	132365490	132365599

Expression profiles

Bgee: expression breadth broad, 95 present calls, max score 78.47.

Top tissues by expression

95 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	78.47	gold quality
fundus of stomach	UBERON:0001160	75.53	gold quality
adenohypophysis	UBERON:0002196	74.97	gold quality
bone marrow	UBERON:0002371	74.34	gold quality
placenta	UBERON:0001987	72.90	gold quality
blood	UBERON:0000178	72.72	gold quality
duodenum	UBERON:0002114	71.50	gold quality
islet of Langerhans	UBERON:0000006	71.09	gold quality
liver	UBERON:0002107	70.70	gold quality
muscle of leg	UBERON:0001383	69.33	gold quality
right lobe of liver	UBERON:0001114	69.10	gold quality
kidney	UBERON:0002113	69.09	gold quality
metanephros cortex	UBERON:0010533	68.71	gold quality
gastrocnemius	UBERON:0001388	68.46	gold quality
left adrenal gland cortex	UBERON:0035825	67.77	gold quality
heart left ventricle	UBERON:0002084	67.72	gold quality
popliteal artery	UBERON:0002250	67.48	gold quality
tibial artery	UBERON:0007610	67.44	gold quality
gall bladder	UBERON:0002110	66.67	gold quality
right hemisphere of cerebellum	UBERON:0014890	66.54	gold quality
body of stomach	UBERON:0001161	66.51	gold quality
cerebellar hemisphere	UBERON:0002245	66.37	gold quality
apex of heart	UBERON:0002098	66.33	gold quality
urinary bladder	UBERON:0001255	66.02	gold quality
endocervix	UBERON:0000458	65.84	gold quality
Ammon’s horn	UBERON:0001954	65.83	gold quality
stomach	UBERON:0000945	65.74	gold quality
adrenal tissue	UBERON:0018303	65.26	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	65.21	gold quality
left ovary	UBERON:0002119	65.14	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.