MIR3937

Summary

MIR3937 (microRNA 3937, HGNC:38970) is a microRNA gene on chromosome Xp11.4.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500822 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38970
Approved symbol	MIR3937
Name	microRNA 3937
Location	Xp11.4
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3937
Ensembl gene	ENSG00000263730
Ensembl biotype	miRNA
Entrez	100500822
RNAcentral	URS000075E234 — miRNA, 106 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580135

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580135 — 1 exons

Exon	Start	End
ENSE00002729544	39661216	39661321

Expression profiles

Bgee: expression breadth tissue_specific, 9 present calls, max score 79.24.

Top tissues by expression

9 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	79.24	gold quality
tibial artery	UBERON:0007610	68.38	gold quality
left ovary	UBERON:0002119	67.40	gold quality
caudate nucleus	UBERON:0001873	65.47	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.24	gold quality
Ammon’s horn	UBERON:0001954	60.29	gold quality
tibial nerve	UBERON:0001323	56.99	gold quality
corpus callosum	UBERON:0002336	49.46	silver quality
testis	UBERON:0000473	41.64	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.99

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.