MIR3938

Summary

MIR3938 (microRNA 3938, HGNC:38972) is a microRNA gene on chromosome 3p14.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500875 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38972
Approved symbol	MIR3938
Name	microRNA 3938
Location	3p14.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3938
Ensembl gene	ENSG00000264013
Ensembl biotype	miRNA
Entrez	100500875
RNAcentral	URS000075E1AC — miRNA, 103 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582157

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582157 — 1 exons

Exon	Start	End
ENSE00002726038	55852492	55852594

Expression profiles

Bgee: expression breadth broad, 16 present calls, max score 96.47.

Top tissues by expression

16 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	96.47	gold quality
blood	UBERON:0000178	90.89	gold quality
kidney	UBERON:0002113	84.90	gold quality
heart	UBERON:0000948	80.54	gold quality
adrenal tissue	UBERON:0018303	78.93	gold quality
monocyte	CL:0000576	75.07	gold quality
stomach	UBERON:0000945	67.82	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.28	gold quality
right hemisphere of cerebellum	UBERON:0014890	66.82	gold quality
right frontal lobe	UBERON:0002810	65.10	gold quality
anterior cingulate cortex	UBERON:0009835	64.38	gold quality
Brodmann (1909) area 9	UBERON:0013540	64.18	gold quality
pituitary gland	UBERON:0000007	63.24	gold quality
cerebellar hemisphere	UBERON:0002245	61.88	gold quality
Ammon’s horn	UBERON:0001954	60.43	gold quality
corpus callosum	UBERON:0002336	57.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.99

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• CircCDK14 Promotes Tumor Progression and Resists Ferroptosis in Glioma by Regulating PDGFRA. (PMID:35002529)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.