MIR3939

Summary

MIR3939 (microRNA 3939, HGNC:38931) is a microRNA gene on chromosome 6q27.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500857 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38931
Approved symbol	MIR3939
Name	microRNA 3939
Location	6q27
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3939
Ensembl gene	ENSG00000265828
Ensembl biotype	miRNA
Entrez	100500857
RNAcentral	URS0000759FD9 — miRNA, 106 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582614

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582614 — 1 exons

Exon	Start	End
ENSE00002713931	166997807	166997912

Expression profiles

Bgee: expression breadth ubiquitous, 172 present calls, max score 94.70.

Top tissues by expression

216 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	94.70	gold quality
blood	UBERON:0000178	85.84	gold quality
trabecular bone tissue	UBERON:0002483	84.52	gold quality
bone marrow	UBERON:0002371	84.49	gold quality
thymus	UBERON:0002370	83.39	gold quality
calcaneal tendon	UBERON:0003701	81.11	gold quality
jejunal mucosa	UBERON:0000399	80.18	gold quality
adrenal tissue	UBERON:0018303	79.70	gold quality
Brodmann (1909) area 9	UBERON:0013540	79.55	gold quality
monocyte	CL:0000576	78.55	gold quality
sperm	CL:0000019	77.95	gold quality
oral cavity	UBERON:0000167	77.89	gold quality
nipple	UBERON:0002030	74.90	gold quality
epithelium of nasopharynx	UBERON:0001951	74.80	gold quality
superficial temporal artery	UBERON:0001614	74.51	gold quality
right lobe of liver	UBERON:0001114	74.47	gold quality
body of pancreas	UBERON:0001150	74.07	gold quality
lymph node	UBERON:0000029	73.34	gold quality
ileal mucosa	UBERON:0000331	72.15	gold quality
liver	UBERON:0002107	72.04	gold quality
muscle layer of sigmoid colon	UBERON:0035805	71.74	gold quality
minor salivary gland	UBERON:0001830	71.69	gold quality
caput epididymis	UBERON:0004358	71.51	gold quality
tibial artery	UBERON:0007610	71.19	gold quality
jejunum	UBERON:0002115	71.07	gold quality
body of stomach	UBERON:0001161	71.02	gold quality
duodenum	UBERON:0002114	70.68	gold quality
transverse colon	UBERON:0001157	70.54	gold quality
ascending aorta	UBERON:0001496	70.33	gold quality
bronchial epithelial cell	CL:0002328	70.32	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.38

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.