MIR3940

Summary

MIR3940 (microRNA 3940, HGNC:38893) is a microRNA gene on chromosome 19p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500888 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38893
Approved symbol	MIR3940
Name	microRNA 3940
Location	19p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3940
Ensembl gene	ENSG00000284159
Ensembl biotype	miRNA
Entrez	100500888
RNAcentral	URS000075BFE0 — miRNA, 102 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579148

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579148 — 1 exons

Exon	Start	End
ENSE00002730978	6416410	6416511

Expression profiles

Bgee: expression breadth broad, 90 present calls, max score 77.09.

Top tissues by expression

90 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	77.09	gold quality
monocyte	CL:0000576	76.63	gold quality
gastrocnemius	UBERON:0001388	74.20	gold quality
body of pancreas	UBERON:0001150	73.60	gold quality
right adrenal gland cortex	UBERON:0035827	73.55	gold quality
left uterine tube	UBERON:0001303	73.35	gold quality
ectocervix	UBERON:0012249	73.06	gold quality
right lobe of liver	UBERON:0001114	72.96	gold quality
bone marrow	UBERON:0002371	72.56	gold quality
liver	UBERON:0002107	72.55	gold quality
body of stomach	UBERON:0001161	72.30	gold quality
stomach	UBERON:0000945	71.94	gold quality
right adrenal gland	UBERON:0001233	71.52	gold quality
mucosa of stomach	UBERON:0001199	71.09	gold quality
heart left ventricle	UBERON:0002084	71.04	gold quality
skin of abdomen	UBERON:0001416	70.62	gold quality
transverse colon	UBERON:0001157	70.35	gold quality
heart	UBERON:0000948	70.21	gold quality
left adrenal gland	UBERON:0001234	70.21	gold quality
right ovary	UBERON:0002118	70.20	gold quality
adrenal gland	UBERON:0002369	70.18	gold quality
body of uterus	UBERON:0009853	70.05	gold quality
right atrium auricular region	UBERON:0006631	69.96	gold quality
adrenal tissue	UBERON:0018303	69.95	gold quality
blood	UBERON:0000178	69.92	gold quality
left ovary	UBERON:0002119	69.92	gold quality
left adrenal gland cortex	UBERON:0035825	69.72	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.69	gold quality
tibial artery	UBERON:0007610	69.66	gold quality
esophagus mucosa	UBERON:0002469	69.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.21

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• These findings suggest that miR-150 and miR-3940-5p interfere in non-small cell lung carcinoma tumorigenesis and progression, and in the direct or indirect pathways of miR-150 and miR-3940-5p to affect p53 expression. (PMID:23228962)
• this study shows that downregulation of miR-3940-5p promotes T-cell activity by targeting the cytokine receptor IL-2R gamma on human cutaneous T-cell lines (PMID:27502164)
• MiR-3940-5p promotes granulosa cell proliferation through targeting KCNA5 in polycystic ovarian syndrome. (PMID:32019676)
• Mesenchymal Stem Cell-Derived Exosomal microRNA-3940-5p Inhibits Colorectal Cancer Metastasis by Targeting Integrin alpha6. (PMID:32671583)
• Placental miR-3940-3p Is Associated With Maternal Insulin Resistance in Late Pregnancy. (PMID:34333643)
• Circular RNA F-circEA-2a expression is increased in gastric adenocarcinoma and inhibits the transition from premature microRNA-3940-5p to mature microRNA-3940-5p. (PMID:35235752)
• Long non-coding RNA BBOX1-antisense RNA 1 enhances cell proliferation and migration and suppresses apoptosis in oral squamous cell carcinoma via the miR-3940-3p/laminin subunit gamma 2 axis. (PMID:35506252)
• Hsa_Circ_0000021 Sponges miR-3940-3p/KPNA2 Expression to Promote Cervical Cancer Progression. (PMID:36799424)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.