MIR3941

Summary

MIR3941 (microRNA 3941, HGNC:38949) is a microRNA gene on chromosome 10q26.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500866 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38949
Approved symbol	MIR3941
Name	microRNA 3941
Location	10q26.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3941
Ensembl gene	ENSG00000265442
Ensembl biotype	miRNA
Entrez	100500866
RNAcentral	URS000075E4D1 — miRNA, 103 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582572

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582572 — 1 exons

Exon	Start	End
ENSE00002686317	122416965	122417067

Expression profiles

Bgee: expression breadth broad, 97 present calls, max score 92.68.

Top tissues by expression

97 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	92.68	gold quality
endometrium	UBERON:0001295	79.99	gold quality
blood	UBERON:0000178	77.05	gold quality
calcaneal tendon	UBERON:0003701	77.05	gold quality
ectocervix	UBERON:0012249	77.01	gold quality
muscle of leg	UBERON:0001383	75.04	gold quality
gastrocnemius	UBERON:0001388	74.64	gold quality
placenta	UBERON:0001987	74.41	gold quality
monocyte	CL:0000576	74.39	gold quality
skin of abdomen	UBERON:0001416	74.38	gold quality
liver	UBERON:0002107	74.22	gold quality
kidney	UBERON:0002113	73.71	gold quality
stomach	UBERON:0000945	73.70	gold quality
vagina	UBERON:0000996	73.40	gold quality
body of pancreas	UBERON:0001150	73.14	gold quality
heart	UBERON:0000948	73.06	gold quality
ascending aorta	UBERON:0001496	72.95	gold quality
zone of skin	UBERON:0000014	72.94	gold quality
right atrium auricular region	UBERON:0006631	72.79	gold quality
thoracic aorta	UBERON:0001515	72.73	gold quality
adult mammalian kidney	UBERON:0000082	72.60	gold quality
fundus of stomach	UBERON:0001160	72.38	gold quality
right lobe of liver	UBERON:0001114	72.09	gold quality
islet of Langerhans	UBERON:0000006	71.95	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	71.95	gold quality
skin of leg	UBERON:0001511	71.93	gold quality
left coronary artery	UBERON:0001626	71.91	gold quality
left ovary	UBERON:0002119	71.88	gold quality
heart left ventricle	UBERON:0002084	71.69	gold quality
body of uterus	UBERON:0009853	71.45	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.80

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• miR-3941 targets and down-regulates IGBP1 most speci fi cally in lung adenocarcinoma cell line, and induces apoptosis. (PMID:28012229)
• The expression of miR-3941 was significantly down-regulated in acute pneumonia; IGF2 was confirmed as a direct target gene of miR-3941. (PMID:29328418)
• carcinogenic role of lncRNA RP11-552M11.4 in CC was mediated through miR-3941/ATF1 axis (PMID:30790638)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.