MIR3943

Summary

MIR3943 (microRNA 3943, HGNC:38888) is a microRNA gene on chromosome 7p14.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500829 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38888
Approved symbol	MIR3943
Name	microRNA 3943
Location	7p14.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3943
Ensembl gene	ENSG00000264069
Ensembl biotype	miRNA
Entrez	100500829
RNAcentral	URS000075CCF9 — miRNA, 100 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585069

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585069 — 1 exons

Exon	Start	End
ENSE00002727056	43150895	43150994

Expression profiles

Bgee: expression breadth broad, 35 present calls, max score 89.95.

Top tissues by expression

35 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	89.95	gold quality
left testis	UBERON:0004533	88.62	gold quality
testis	UBERON:0000473	88.36	gold quality
tibial nerve	UBERON:0001323	79.01	gold quality
lung	UBERON:0002048	78.35	gold quality
monocyte	CL:0000576	77.13	gold quality
gastrocnemius	UBERON:0001388	76.14	gold quality
blood	UBERON:0000178	73.73	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.21	gold quality
lower esophagus	UBERON:0013473	68.71	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.66	gold quality
right frontal lobe	UBERON:0002810	67.61	gold quality
left ovary	UBERON:0002119	67.27	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.06	gold quality
amygdala	UBERON:0001876	66.75	gold quality
nucleus accumbens	UBERON:0001882	66.55	gold quality
caudate nucleus	UBERON:0001873	66.26	gold quality
skin of leg	UBERON:0001511	65.90	gold quality
small intestine Peyer’s patch	UBERON:0003454	65.51	gold quality
putamen	UBERON:0001874	65.38	gold quality
right ovary	UBERON:0002118	65.32	gold quality
Ammon’s horn	UBERON:0001954	64.64	gold quality
corpus callosum	UBERON:0002336	64.47	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.29	gold quality
cerebellar hemisphere	UBERON:0002245	64.13	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	63.74	gold quality
left lobe of thyroid gland	UBERON:0001120	63.45	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.70	gold quality
prostate gland	UBERON:0002367	61.58	gold quality
skin of abdomen	UBERON:0001416	61.19	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.65

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.