MIR3944

Summary

MIR3944 (microRNA 3944, HGNC:38898) is a microRNA gene on chromosome 10q26.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500911 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38898
Approved symbol	MIR3944
Name	microRNA 3944
Location	10q26.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3944
Ensembl gene	ENSG00000265395
Ensembl biotype	miRNA
Entrez	100500911
RNAcentral	URS000075DF2F — miRNA, 108 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581277

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581277 — 1 exons

Exon	Start	End
ENSE00002729090	133371556	133371663

Expression profiles

Bgee: expression breadth broad, 86 present calls, max score 87.71.

Top tissues by expression

86 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	87.71	gold quality
urinary bladder	UBERON:0001255	79.60	gold quality
duodenum	UBERON:0002114	79.02	gold quality
monocyte	CL:0000576	78.52	gold quality
bone marrow	UBERON:0002371	76.52	gold quality
small intestine	UBERON:0002108	76.07	gold quality
small intestine Peyer’s patch	UBERON:0003454	75.94	gold quality
right lobe of liver	UBERON:0001114	75.92	gold quality
liver	UBERON:0002107	74.44	gold quality
blood	UBERON:0000178	74.12	gold quality
placenta	UBERON:0001987	73.72	gold quality
granulocyte	CL:0000094	73.70	gold quality
gastrocnemius	UBERON:0001388	73.56	gold quality
vermiform appendix	UBERON:0001154	73.51	gold quality
adrenal tissue	UBERON:0018303	73.51	gold quality
islet of Langerhans	UBERON:0000006	73.34	gold quality
adult mammalian kidney	UBERON:0000082	73.04	gold quality
left uterine tube	UBERON:0001303	72.84	gold quality
body of pancreas	UBERON:0001150	72.57	gold quality
stomach	UBERON:0000945	72.27	gold quality
body of stomach	UBERON:0001161	71.80	gold quality
kidney	UBERON:0002113	71.56	gold quality
transverse colon	UBERON:0001157	70.76	gold quality
colon	UBERON:0001155	70.36	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.04	gold quality
tibial artery	UBERON:0007610	69.96	gold quality
putamen	UBERON:0001874	69.37	gold quality
right atrium auricular region	UBERON:0006631	69.36	gold quality
fundus of stomach	UBERON:0001160	69.29	gold quality
esophagus mucosa	UBERON:0002469	69.12	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.15

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.