MIR3945

Summary

MIR3945 (microRNA 3945, HGNC:38954) is a microRNA gene on chromosome 4q35.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500818 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38954
Approved symbol	MIR3945
Name	microRNA 3945
Location	4q35.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3945
Ensembl gene	ENSG00000266698
Ensembl biotype	miRNA
Entrez	100500818
RNAcentral	URS000075C1D9 — miRNA, 98 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581853

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581853 — 1 exons

Exon	Start	End
ENSE00002701113	184851013	184851110

Expression profiles

Bgee: expression breadth broad, 48 present calls, max score 80.89.

Top tissues by expression

48 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	80.89	gold quality
bone marrow	UBERON:0002371	78.76	gold quality
gastrocnemius	UBERON:0001388	77.48	gold quality
adrenal gland	UBERON:0002369	76.61	gold quality
anterior cingulate cortex	UBERON:0009835	75.69	gold quality
blood	UBERON:0000178	75.43	gold quality
vermiform appendix	UBERON:0001154	74.88	gold quality
small intestine Peyer’s patch	UBERON:0003454	74.61	gold quality
placenta	UBERON:0001987	74.53	gold quality
right lobe of liver	UBERON:0001114	73.98	gold quality
heart left ventricle	UBERON:0002084	73.95	gold quality
left coronary artery	UBERON:0001626	73.75	gold quality
muscle layer of sigmoid colon	UBERON:0035805	72.29	gold quality
granulocyte	CL:0000094	71.84	gold quality
right atrium auricular region	UBERON:0006631	71.45	gold quality
colon	UBERON:0001155	71.03	gold quality
omental fat pad	UBERON:0010414	70.36	gold quality
body of stomach	UBERON:0001161	69.88	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.73	gold quality
left uterine tube	UBERON:0001303	68.97	gold quality
substantia nigra	UBERON:0002038	68.84	gold quality
liver	UBERON:0002107	68.83	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.21	gold quality
body of uterus	UBERON:0009853	68.16	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.04	gold quality
ascending aorta	UBERON:0001496	67.81	gold quality
thoracic aorta	UBERON:0001515	67.70	gold quality
descending thoracic aorta	UBERON:0002345	67.37	gold quality
transverse colon	UBERON:0001157	66.87	gold quality
skin of leg	UBERON:0001511	66.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.58

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The upregulation of miR-3945 in CD14+ monocytes is the risk factor for cardiovascular disease. (PMID:37702194)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.