MIR3960

Summary

MIR3960 (microRNA 3960, HGNC:41595) is a microRNA gene on chromosome 9q34.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616250 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41595
Approved symbol	MIR3960
Name	microRNA 3960
Location	9q34.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3960
Ensembl gene	ENSG00000283863
Ensembl biotype	miRNA
Entrez	100616250
RNAcentral	URS000075CBCF — miRNA, 91 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583311

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583311 — 1 exons

Exon	Start	End
ENSE00002732846	127785833	127785923

Expression profiles

Bgee: expression breadth broad, 62 present calls, max score 78.88.

Top tissues by expression

62 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	78.88	gold quality
nucleus accumbens	UBERON:0001882	77.75	gold quality
right lobe of liver	UBERON:0001114	72.89	gold quality
muscle of leg	UBERON:0001383	72.38	gold quality
left coronary artery	UBERON:0001626	72.16	gold quality
gastrocnemius	UBERON:0001388	71.30	gold quality
liver	UBERON:0002107	70.36	gold quality
left adrenal gland	UBERON:0001234	69.63	gold quality
lung	UBERON:0002048	69.21	gold quality
blood	UBERON:0000178	67.59	gold quality
stomach	UBERON:0000945	66.78	gold quality
endometrium	UBERON:0001295	66.16	gold quality
heart left ventricle	UBERON:0002084	66.14	gold quality
body of stomach	UBERON:0001161	65.87	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	65.15	gold quality
putamen	UBERON:0001874	64.98	gold quality
tibial artery	UBERON:0007610	64.50	gold quality
right atrium auricular region	UBERON:0006631	63.70	gold quality
upper lobe of left lung	UBERON:0008952	62.86	gold quality
ascending aorta	UBERON:0001496	61.91	gold quality
skin of leg	UBERON:0001511	61.38	gold quality
lymph node	UBERON:0000029	61.30	gold quality
right frontal lobe	UBERON:0002810	61.11	gold quality
esophagus	UBERON:0001043	60.61	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	60.57	gold quality
right adrenal gland	UBERON:0001233	60.54	gold quality
esophagus mucosa	UBERON:0002469	60.53	gold quality
transverse colon	UBERON:0001157	60.52	gold quality
substantia nigra	UBERON:0002038	60.48	gold quality
lower esophagus muscularis layer	UBERON:0035833	60.19	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Integrated Analysis of mRNA-seq and miRNA-seq to Identify c-MYC, YAP1 and miR-3960 as Major Players in the Anticancer Effects of Caffeic Acid Phenethyl Ester in Human Small Cell Lung Cancer Cell Line. (PMID:32445454)
• LINC01605 regulates proliferation, migration and invasion of colorectal cancer cells via targeting miR-3960/SOX11. (PMID:33629302)
• SOD1-high fibroblasts derived exosomal miR-3960 promotes cisplatin resistance in triple-negative breast cancer by suppressing BRSK2-mediated phosphorylation of PIMREG. (PMID:38582395)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.