MIR3972

Summary

MIR3972 (microRNA 3972, HGNC:41876) is a microRNA gene on chromosome 1p36.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616188 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41876
Approved symbol	MIR3972
Name	microRNA 3972
Location	1p36.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3972
Ensembl gene	ENSG00000266634
Ensembl biotype	miRNA
Entrez	100616188
RNAcentral	URS000075EE34 — miRNA, 87 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582732

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582732 — 1 exons

Exon	Start	End
ENSE00002711854	17277889	17277975

Expression profiles

Bgee: expression breadth broad, 30 present calls, max score 91.53.

Top tissues by expression

30 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus muscularis layer	UBERON:0035833	91.53	gold quality
lower esophagus mucosa	UBERON:0035834	90.01	gold quality
esophagus	UBERON:0001043	83.09	gold quality
esophagus mucosa	UBERON:0002469	83.07	gold quality
urinary bladder	UBERON:0001255	79.04	gold quality
ectocervix	UBERON:0012249	76.70	gold quality
skin of abdomen	UBERON:0001416	74.24	gold quality
minor salivary gland	UBERON:0001830	73.79	gold quality
right lobe of liver	UBERON:0001114	73.11	gold quality
vagina	UBERON:0000996	73.08	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	72.76	gold quality
subcutaneous adipose tissue	UBERON:0002190	72.52	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	71.16	gold quality
sural nerve	UBERON:0015488	70.49	gold quality
prostate gland	UBERON:0002367	70.48	gold quality
left ovary	UBERON:0002119	70.16	gold quality
islet of Langerhans	UBERON:0000006	69.59	gold quality
skin of leg	UBERON:0001511	67.83	gold quality
body of pancreas	UBERON:0001150	67.21	gold quality
tibial nerve	UBERON:0001323	66.83	gold quality
substantia nigra	UBERON:0002038	65.68	gold quality
left lobe of thyroid gland	UBERON:0001120	63.20	gold quality
hypothalamus	UBERON:0001898	61.75	gold quality
spleen	UBERON:0002106	61.29	gold quality
thoracic mammary gland	UBERON:0005200	59.59	gold quality
Brodmann (1909) area 9	UBERON:0013540	59.19	gold quality
right frontal lobe	UBERON:0002810	53.93	gold quality
testis	UBERON:0000473	45.39	gold quality
left testis	UBERON:0004533	43.56	gold quality
right testis	UBERON:0004534	41.68	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.