MIR3975

Summary

MIR3975 (microRNA 3975, HGNC:41613) is a microRNA gene on chromosome 18q12.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616257 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41613
Approved symbol	MIR3975
Name	microRNA 3975
Location	18q12.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3975
Ensembl gene	ENSG00000283514
Ensembl biotype	miRNA
Entrez	100616257
RNAcentral	URS000075A217 — miRNA, 70 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636650

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636650 — 1 exons

Exon	Start	End
ENSE00003800073	35591737	35591806

Expression profiles

Bgee: expression breadth broad, 77 present calls, max score 97.87.

Top tissues by expression

77 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.87	gold quality
skeletal muscle tissue	UBERON:0001134	89.05	gold quality
bone marrow	UBERON:0002371	82.65	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.25	gold quality
adrenal tissue	UBERON:0018303	81.65	gold quality
stomach	UBERON:0000945	81.52	gold quality
blood	UBERON:0000178	81.22	gold quality
kidney	UBERON:0002113	79.71	gold quality
muscle of leg	UBERON:0001383	78.56	gold quality
monocyte	CL:0000576	76.80	gold quality
liver	UBERON:0002107	76.33	gold quality
adult mammalian kidney	UBERON:0000082	75.88	gold quality
heart	UBERON:0000948	75.88	gold quality
heart left ventricle	UBERON:0002084	74.86	gold quality
calcaneal tendon	UBERON:0003701	74.07	gold quality
gastrocnemius	UBERON:0001388	72.74	gold quality
islet of Langerhans	UBERON:0000006	72.64	gold quality
smooth muscle tissue	UBERON:0001135	71.29	gold quality
endometrium	UBERON:0001295	69.90	gold quality
lung	UBERON:0002048	68.98	gold quality
tibial artery	UBERON:0007610	68.97	gold quality
corpus callosum	UBERON:0002336	68.85	gold quality
intestine	UBERON:0000160	68.70	gold quality
colon	UBERON:0001155	68.28	gold quality
right atrium auricular region	UBERON:0006631	68.23	gold quality
multicellular organism	UBERON:0000468	67.91	gold quality
rectum	UBERON:0001052	67.74	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.56	gold quality
myometrium	UBERON:0001296	67.48	gold quality
putamen	UBERON:0001874	67.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.78

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.