MIR3976

Summary

MIR3976 (microRNA 3976, HGNC:41578) is a microRNA gene on chromosome 18p11.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616244 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41578
Approved symbol	MIR3976
Name	microRNA 3976
Location	18p11.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3976
Ensembl gene	ENSG00000272380
Ensembl biotype	miRNA
Entrez	100616244
RNAcentral	URS0000759F9C — miRNA, 139 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000606807

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000606807 — 1 exons

Exon	Start	End
ENSE00003700599	5840695	5840833

Expression profiles

Bgee: expression breadth broad, 12 present calls, max score 75.24.

Top tissues by expression

12 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	75.24	gold quality
tibial artery	UBERON:0007610	70.91	gold quality
adrenal tissue	UBERON:0018303	69.06	gold quality
omental fat pad	UBERON:0010414	68.84	gold quality
calcaneal tendon	UBERON:0003701	66.39	gold quality
corpus callosum	UBERON:0002336	65.69	gold quality
Brodmann (1909) area 9	UBERON:0013540	64.85	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	61.75	gold quality
right frontal lobe	UBERON:0002810	59.79	gold quality
testis	UBERON:0000473	44.44	gold quality
left testis	UBERON:0004533	44.42	gold quality
right testis	UBERON:0004534	44.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.21

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Rs6757 in microRNA-3976 binding site of CD147 confers risk of hepatocellular carcinoma in South Chinese population. (PMID:35978360)
• MiR-3976 regulates HCT-8 cell apoptosis and parasite burden by targeting BCL2A1 in response to Cryptosporidium parvum infection. (PMID:37415254)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.