MIR3977

Summary

MIR3977 (microRNA 3977, HGNC:41721) is a microRNA gene on chromosome 5q14.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616297 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41721
Approved symbol	MIR3977
Name	microRNA 3977
Location	5q14.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3977
Ensembl gene	ENSG00000283359
Ensembl biotype	miRNA
Entrez	100616297
RNAcentral	URS000075B3B6 — miRNA, 70 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636444

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636444 — 1 exons

Exon	Start	End
ENSE00003798768	82840155	82840224

Expression profiles

Bgee: expression breadth broad, 44 present calls, max score 80.09.

Top tissues by expression

44 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	80.09	gold quality
adrenal tissue	UBERON:0018303	79.79	gold quality
muscle of leg	UBERON:0001383	79.15	gold quality
calcaneal tendon	UBERON:0003701	75.74	gold quality
intestine	UBERON:0000160	74.11	gold quality
endometrium	UBERON:0001295	73.17	gold quality
blood	UBERON:0000178	72.11	gold quality
heart	UBERON:0000948	70.16	gold quality
Ammon’s horn	UBERON:0001954	69.18	gold quality
tibial artery	UBERON:0007610	68.22	gold quality
esophagus mucosa	UBERON:0002469	67.52	gold quality
left adrenal gland	UBERON:0001234	67.38	gold quality
anterior cingulate cortex	UBERON:0009835	67.19	gold quality
substantia nigra	UBERON:0002038	67.17	gold quality
thoracic aorta	UBERON:0001515	67.11	gold quality
ascending aorta	UBERON:0001496	67.08	gold quality
left adrenal gland cortex	UBERON:0035825	67.04	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.60	gold quality
amygdala	UBERON:0001876	66.30	gold quality
putamen	UBERON:0001874	65.99	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.88	gold quality
myometrium	UBERON:0001296	64.57	gold quality
caudate nucleus	UBERON:0001873	64.54	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.53	gold quality
vagina	UBERON:0000996	64.51	gold quality
skin of abdomen	UBERON:0001416	64.09	gold quality
skin of leg	UBERON:0001511	64.08	gold quality
adult mammalian kidney	UBERON:0000082	64.02	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	63.93	gold quality
body of stomach	UBERON:0001161	63.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.