MIR3978

Summary

MIR3978 (microRNA 3978, HGNC:41630) is a microRNA gene on chromosome Xq23.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616491 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41630
Approved symbol	MIR3978
Name	microRNA 3978
Location	Xq23
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3978
Ensembl gene	ENSG00000265584
Ensembl biotype	miRNA
Entrez	100616491
RNAcentral	URS000075D60F — miRNA, 101 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585195

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585195 — 1 exons

Exon	Start	End
ENSE00002685951	110082118	110082218

Expression profiles

Bgee: expression breadth broad, 53 present calls, max score 85.45.

Top tissues by expression

53 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	85.45	gold quality
kidney	UBERON:0002113	83.31	gold quality
adrenal tissue	UBERON:0018303	78.81	gold quality
monocyte	CL:0000576	78.64	gold quality
calcaneal tendon	UBERON:0003701	77.66	gold quality
lower esophagus muscularis layer	UBERON:0035833	75.80	gold quality
stomach	UBERON:0000945	75.61	gold quality
adult mammalian kidney	UBERON:0000082	74.77	gold quality
liver	UBERON:0002107	74.15	gold quality
putamen	UBERON:0001874	72.69	gold quality
tibial artery	UBERON:0007610	72.24	gold quality
gastrocnemius	UBERON:0001388	72.19	gold quality
heart	UBERON:0000948	72.12	gold quality
heart left ventricle	UBERON:0002084	71.53	gold quality
right atrium auricular region	UBERON:0006631	71.17	gold quality
intestine	UBERON:0000160	70.20	gold quality
body of stomach	UBERON:0001161	68.82	gold quality
colon	UBERON:0001155	68.78	gold quality
body of uterus	UBERON:0009853	68.25	gold quality
body of pancreas	UBERON:0001150	67.91	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.11	gold quality
caudate nucleus	UBERON:0001873	66.97	gold quality
omental fat pad	UBERON:0010414	66.97	gold quality
skin of leg	UBERON:0001511	66.89	gold quality
tibial nerve	UBERON:0001323	66.87	gold quality
lung	UBERON:0002048	66.61	gold quality
left ovary	UBERON:0002119	66.39	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.28	gold quality
skin of abdomen	UBERON:0001416	66.01	gold quality
esophagus mucosa	UBERON:0002469	65.71	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.36

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• MiRNA-3978 regulates peritoneal gastric cancer metastasis by targeting legumain expression, promoting cell migration/neoplasm invasiveness. (PMID:27793040)
• PCBP1 and miR-3978 are sequestered in normal peritoneal tissue, but disrupted following metastatic progression. PCBP1 expression mimicked miR-3978 expression across gastric cancer patients. Replenishment of miR-3978 in the peritoneal metastasis cell line MKN45 resulted in induction of PCBP1 protein expression, potentially indicating that miR-3978 expression might downregulate a negative regulator targeting PCBP1. (PMID:29138420)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.