MIR410

Summary

MIR410 (microRNA 410, HGNC:32065) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574434 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32065
Approved symbol	MIR410
Name	microRNA 410
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-410
Ensembl gene	ENSG00000199092
Ensembl biotype	miRNA
OMIM	615036
Entrez	574434
RNAcentral	URS0000717C38 — miRNA, 80 nt, 7 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362222

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362222 — 1 exons

Exon	Start	End
ENSE00001436985	101065912	101065991

Expression profiles

Bgee: expression breadth broad, 85 present calls, max score 88.79.

Top tissues by expression

85 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	88.79	gold quality
placenta	UBERON:0001987	87.64	gold quality
skeletal muscle tissue	UBERON:0001134	86.57	gold quality
monocyte	CL:0000576	79.58	gold quality
left ovary	UBERON:0002119	75.89	gold quality
muscle of leg	UBERON:0001383	75.36	gold quality
blood	UBERON:0000178	75.27	gold quality
adrenal gland	UBERON:0002369	74.84	gold quality
vagina	UBERON:0000996	74.36	gold quality
left adrenal gland cortex	UBERON:0035825	74.07	gold quality
ovary	UBERON:0000992	74.05	gold quality
left adrenal gland	UBERON:0001234	73.05	gold quality
body of pancreas	UBERON:0001150	72.76	gold quality
smooth muscle tissue	UBERON:0001135	72.34	gold quality
right adrenal gland	UBERON:0001233	72.19	gold quality
endometrium	UBERON:0001295	72.13	gold quality
stomach	UBERON:0000945	72.12	gold quality
liver	UBERON:0002107	71.90	gold quality
adipose tissue	UBERON:0001013	71.89	gold quality
omental fat pad	UBERON:0010414	71.52	gold quality
islet of Langerhans	UBERON:0000006	71.02	gold quality
body of stomach	UBERON:0001161	70.69	gold quality
fallopian tube	UBERON:0003889	70.57	gold quality
gastrocnemius	UBERON:0001388	70.27	gold quality
right adrenal gland cortex	UBERON:0035827	70.13	gold quality
heart	UBERON:0000948	70.07	gold quality
right lobe of liver	UBERON:0001114	69.98	gold quality
lung	UBERON:0002048	69.87	gold quality
prefrontal cortex	UBERON:0000451	69.84	gold quality
heart left ventricle	UBERON:0002084	69.64	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• Expression of miR-487b and miR-410 shows predictive value beyond the classical high-/low-risk stratification and is a biomarker of relapse in favourable neuroblastoma. (PMID:21970883)
• miR-410, a direct regulator of MET, may function as a tumor suppressor in human gliomas. (PMID:22750473)
• Our results suggest that rs13702 induces the allele-specific regulation of LPL by miR-410 in humans. (PMID:23246289)
• mechanism of how miR-410 targets VEGFA (PMID:24777200)
• Data from cohorts in Spain suggest an SNP in microRNA-410 recognition element in 3prime-untranslated region of lipoprotein lipase (rs13702) is associated with response to Mediterranean diet in treatment of hypertriglyceridemia and stroke prevention. (PMID:24990426)
• Our results suggest that miR-410 may function as an oncomiR and are consistent with its key function in regulating FHL1 in certain digestive system cancers. (PMID:25272045)
• We showed that miR-410 directly regulates predicted target genes OTX2 and RPE65. (PMID:25351180)
• Stable ectopic expression of Wnt-7b in OSCC cells overexpressing miR329 or miR410 restored proliferation and invasion capabilities abolished by these miRNA (PMID:25351956)
• Our findings suggest a cooperative relationship between miR-410 and VEGF in OS cell regulation. (PMID:25385479)
• miR-410 suppresses pancreatic cancer growth, cell invasion, migration, and angiogenesis via the downregulation of AGTR1, acting as a tumor-suppressive miRNA. (PMID:25646808)
• CCNB1 is target of miRNA-410 since its overexpression reduces CCNB1 at protein and mRNA levels. (PMID:26125663)
• Data indicate that bromodomain-containing protein 7 (BRD7) was a direct target of microRNA-410 (miR-410). (PMID:26149213)
• miR-410 enhanced hESC-derived pancreatic endoderm transplant to alleviate gestational diabetes mellitus (PMID:26307561)
• The results suggest a regulatory role of miRNA-410 in modulating levels of MMP-14 in endometrial cancer (PMID:26842619)
• High miR410 expression is associated with non-small cell lung cancer. (PMID:26910912)
• the expression of Bak1 was downregulated in CRC tumor tissues and was reversely correlated with the expression of miR410, which provided further support that Bak1 was regulated by miR410. (PMID:27177325)
• MiR410-3p was inversely expressed with Snail in breast cancer samples. (PMID:27221455)
• our study revealed a novel microRNA signaling pathway involved in cholangiocarcinoma and suggests that manipulation of the miR-410/XIAP pathway could have a therapeutic potential for cholangiocarcinoma (PMID:27259577)
• Data indicate that microRNA miR-410 is the key regulatory factor in the pathogenesis of systemic lupus erythematosus (SLE) by regulating the expression of IL-10 through targeting STAT3. (PMID:27351906)
• These data demonstrated that lncRNA-CCAT1 promoted glioma cell proliferation via inhibiting miR-410, providing a new insight about the pathogenesis of glioma proliferation. (PMID:27765628)
• our findings identify the miR-410/Gsk3beta/beta-catenin signaling axis is a novel molecular circuit in inducing stemness of non-small cells lung cancer (PMID:28076327)
• MicroRNA-410 regulates autophagy-related gene ATG16L1 expression and enhances chemosensitivity via autophagy inhibition in osteosarcoma. (PMID:28138700)
• The dendritic cell-internalized miR-410-5p degraded the miR-410-3p by base pairing and thus inhibited its function in suppressing tumor angiogenesis, promoting tumor growth. (PMID:28529626)
• Overexpression of MMP2 and MMP16 in endometrial cancerous tissues corresponded to down-regulation of miR-377, miR-382 and miR-410, while decreased expression of TIMP2 was associated with miR-200b up-regulation. (PMID:28871006)
• Data indicated that miR-410 functions as a promoter of myocardial I/R injury by directly targeting HMGB1, thus enhancing mitochondrial dysfunction and cardiomyocyte apoptosis. (PMID:28914970)
• Authors showed that hUCMSC-EV-mediated LUAD growth is associated with increased proliferation and decreased apoptosis in LUAD cells, concomitant with reduced PTEN expression mediated by the hUCMSC-EV-transmitted miR-410. (PMID:29440630)
• PTEN is known as a key negative modulator of the PI3K/AKT pathway. These findings indicated that upregulation of miR-410-3p resulted in the down-regulation of PTEN, thereby activating the AKT/mTOR pathway. miR-410-3p inhibits prostate cancer progression via downregulating PTEN/AKT/mTOR signaling pathway. (PMID:29969630)
• MiR-410 plays anti-tumor roles by directly targeting ERLIN2, acting as a tumor suppressor in ER(+) breast cancer. Moreover, the downregulation of miR-410 was related to promoter hypermethylation. (PMID:30016800)
• this review comprehensively summarizes most recent evidence available related to the “split personality” of miR-410 in different cancers. (PMID:30086210)
• miR-410-3p acts as an inflammatory suppressor in the pathogenesis of RA by regulating the NF-kappaB signaling pathway. (PMID:30242542)
• MiR410 was up-regulated in pediatric acute lymphoblastic leukemia (ALL) cases and cells. Bioinformatics analysis and luciferase reporter assay revealed FKBP5 as a direct target of miR410. The overexpression of miR410 accelerated the proliferation and colony formation ability of ALL cells, decreasing cell apoptosis rate by inhibiting activation of Akt signaling pathway. However, FKBP5 could reverse the effects of miR410. (PMID:30575921)
• Data implied that miR-410 exerted its neuroprotective effects via regulating PTEN/AKT/mTOR signaling axis. (PMID:31067440)
• We have found that the level of expression of miR-410-3p differs in particular types of pituitary adenomas (PMID:31165412)
• demonstration for the first time miR-410 expression in human dental pulp and that expression of this microRNA was downregulated in inflamed dental pulp and odontoblasts (PMID:31486923)
• YY1 up-regulation was able to rescue the effects of miR-410-3p in rheumatoid arthritis fibroblast-like synoviocytes. (PMID:31505424)
• Overexpression of miRNA-410-3p protects hypoxia-induced cardiomyocyte injury via targeting TRAF5. (PMID:31696495)
• Up-regulation of miR-410 restrained HMGB1 levels and NEAT1 can regulate HMGB1 level via sponging miR-410. (PMID:31734579)
• Long non-coding RNA FTX alleviates hypoxia/reoxygenation-induced cardiomyocyte injury via miR-410-3p/Fmr1 axis. (PMID:31957854)
• Upregulated miR-410 is linked to poor prognosis in colorectal cancer. (PMID:32065051)
• miR-410 induces both epithelial-mesenchymal transition and radioresistance through activation of the PI3K/mTOR pathway in non-small cell lung cancer. (PMID:32528035)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir410	ENSMUSG00000065497
rattus_norvegicus	Mir410	ENSRNOG00000035557

Paralogs (16): MIR494 (ENSG00000194717), MIR377 (ENSG00000199015), MIR381 (ENSG00000199020), MIR369 (ENSG00000199025), MIR323A (ENSG00000199069), MIR409 (ENSG00000199107), MIR539 (ENSG00000202560), MIR487A (ENSG00000207742), MIR487B (ENSG00000207754), MIR656 (ENSG00000207959), MIR496 (ENSG00000207961), MIR154 (ENSG00000207978), MIR323B (ENSG00000208004), MIR1185-1 (ENSG00000221525), MIR1185-2 (ENSG00000221614), MIR382 (ENSG00000283170)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.