MIR411

Summary

MIR411 (microRNA 411, HGNC:32792) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693121 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32792
Approved symbol	MIR411
Name	microRNA 411
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-411
Ensembl gene	ENSG00000199109
Ensembl biotype	miRNA
Entrez	693121
RNAcentral	URS0000759C2D — miRNA, 96 nt, 22 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362239

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362239 — 1 exons

Exon	Start	End
ENSE00001437002	101023325	101023420

Expression profiles

Bgee: expression breadth broad, 52 present calls, max score 92.23.

Top tissues by expression

52 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	92.23	gold quality
intestine	UBERON:0000160	80.16	gold quality
lung	UBERON:0002048	80.12	gold quality
stomach	UBERON:0000945	79.57	gold quality
heart	UBERON:0000948	75.83	gold quality
monocyte	CL:0000576	75.81	gold quality
colon	UBERON:0001155	75.53	gold quality
prostate gland	UBERON:0002367	75.26	gold quality
islet of Langerhans	UBERON:0000006	74.94	gold quality
body of pancreas	UBERON:0001150	74.12	gold quality
blood	UBERON:0000178	72.17	gold quality
liver	UBERON:0002107	71.81	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.37	gold quality
calcaneal tendon	UBERON:0003701	71.10	gold quality
right adrenal gland cortex	UBERON:0035827	71.08	gold quality
Ammon’s horn	UBERON:0001954	70.87	gold quality
left adrenal gland cortex	UBERON:0035825	70.15	gold quality
ascending aorta	UBERON:0001496	69.33	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.06	gold quality
transverse colon	UBERON:0001157	69.04	gold quality
left uterine tube	UBERON:0001303	68.34	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.11	gold quality
skin of abdomen	UBERON:0001416	67.95	gold quality
esophagus mucosa	UBERON:0002469	67.63	gold quality
body of stomach	UBERON:0001161	67.62	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.26	gold quality
left ovary	UBERON:0002119	67.07	gold quality
multicellular organism	UBERON:0000468	66.79	gold quality
thyroid gland	UBERON:0002046	66.14	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 29)

• study demonstrated that miR-411 was differentially expressed in FSHD myoblasts and may play a role in regulating myogenesis (PMID:23561550)
• High miR-411 expression is associated with aggressive lung adenocarcinoma. (PMID:24833665)
• miR-379 and miR-411 directly target the IL-18 gene and contribute to drug resistance in malignant pleural mesothelioma. (PMID:25231602)
• In hepatocellular carcinoma cells, miR-411 promoted cell proliferation. (PMID:25776495)
• our study revealed miR-411 promoted cell proliferation of lung cancer by targeting tumor suppressor gene FOXO1 and miR-411 might be a potential target for lung cancer therapy. (PMID:26572153)
• investigated the target and mechanism of miR-411-5p in breast cancer using mimic and inhibitor, and demonstrated the involvement of GRB2 and Ras activation (PMID:27264952)
• It was found that miR411 was significantly downregulated in breast cancer, and associated with lymph node metastasis and histological grade. Additionally, it was observed that miR411 suppressed cell growth, migration and invasion in the breast cancer cells. miRNA-411 acts as a potential tumor suppressor miRNA via the downregulation of specificity protein 1 in breast cancer. (PMID:27572271)
• To sum up, miR-411 is significantly down-regulated and plays a role as a tumor suppressor in renal cell carcinoma (RCC). Further studies are warranted to determine the mechanisms of miR-411 in RCC pathogenesis and define the target genes of miR-411 in RCC. (PMID:28708205)
• Study shows that miR-411-5p edited in position 5 was significantly dysregulated in tissues as well as in exosomes of Non-Small Cell Lung Cancer (NSCLC) patients, suggesting a potential targetome shift relevant to lung cancer biology. (PMID:29976955)
• Overexpression of circular RNA circ_001569 indicates poor prognosis in hepatocellular carcinoma and promotes cell growth and metastasis by sponging miR-411-5p and miR-432-5p. (PMID:30086881)
• SLC27A2 is required for the transcriptional induction of miR-411 in ovarian cancer. Reduced miR-411 expression contributes to ovarian cancer chemo-resistance. (PMID:30334452)
• miR-411-5p/3p are required for Non small cell lung carcinoma development by suppressing SPRY4 and TXNIP; thus, the miR-411-SPRY4-AKT axis might act as a promising target for lung cancer therapy clinically. (PMID:30390072)
• MiR-411 inhibits gastric cancer proliferation and migration through targeting SETD6. (PMID:31081088)
• Low miR411 Expression Promotes Renal Cell Carcinoma Progression. (PMID:31476285)
• MicroRNA-411 and Its 5’-IsomiR Have Distinct Targets and Functions and Are Differentially Regulated in the Vasculature under Ischemia. (PMID:31636041)
• MicroRNA-411 plays a protective role in diabetic retinopathy through targeted regulating Robo4. (PMID:31773667)
• miRNA-411 Regulates Chondrocyte Autophagy in Osteoarthritis by Targeting Hypoxia-Inducible Factor 1 alpha (HIF-1alpha). (PMID:32072994)
• Up-regulation of SNHG15 facilitates cell proliferation, migration, invasion and suppresses cell apoptosis in breast cancer by regulating miR-411-5p/VASP axis. (PMID:32141559)
• Up-regulation of circ_0000353 impedes the proliferation and metastasis of non-small cell lung cancer cells via adsorbing miR-411-5p and increasing forkhead box O1. (PMID:32568175)
• Dysregulation of LncRNA ANRIL mediated by miR-411-3p inhibits the malignant proliferation and tumor stem cell like property of multiple myeloma via hypoxia-inducible factor 1alpha. (PMID:32961145)
• Upregulated miR4115p levels promote lymph node metastasis by targeting RYBP in head and neck squamous cell carcinoma. (PMID:33537835)
• Circ_0082182 promotes oncogenesis and metastasis of colorectal cancer in vitro and in vivo by sponging miR-411 and miR-1205 to activate the Wnt/beta-catenin pathway. (PMID:33596920)
• Interference with lncRNA NEAT1 promotes the proliferation, migration, and invasion of trophoblasts by upregulating miR-411-5p and inhibiting PTEN expression. (PMID:33876722)
• Long noncoding RNA PCED1BAS1 promotes pancreatic ductal adenocarcinoma progression by regulating the miR4113p/HIF1alpha axis. (PMID:34036383)
• Long non-coding RNA PSMA3-AS1 promotes glioma progression through modulating the miR-411-3p/HOXA10 pathway. (PMID:34294084)
• The alerting expression of microRNA-411 predicts clinical prognosis and regulates tumor progression of glioblastoma. (PMID:34606414)
• Dysregulation of miR-411 in cancer: Causative factor for pathogenesis, diagnosis and prognosis. (PMID:35358797)
• Circulatory miR-411-5p as a Novel Prognostic Biomarker for Major Adverse Cardiovascular Events in Patients with Atrial Fibrillation. (PMID:36835272)
• A-to-I edited miR-411-5p targets MET and promotes TKI response in NSCLC-resistant cells. (PMID:37002315)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
rattus_norvegicus	Mir411	ENSRNOG00000035574

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.