MIR412

Summary

MIR412 (microRNA 412, HGNC:32064) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574433 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32064
Approved symbol	MIR412
Name	microRNA 412
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-412
Ensembl gene	ENSG00000199012
Ensembl biotype	miRNA
Entrez	574433
RNAcentral	URS00006FAA35 — miRNA, 91 nt, 15 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362142

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362142 — 1 exons

Exon	Start	End
ENSE00001436905	101065447	101065537

Expression profiles

Bgee: expression breadth broad, 76 present calls, max score 91.27.

Top tissues by expression

76 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	91.27	gold quality
sural nerve	UBERON:0015488	87.60	gold quality
skeletal muscle tissue	UBERON:0001134	83.90	gold quality
placenta	UBERON:0001987	80.93	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	79.08	gold quality
left ovary	UBERON:0002119	77.68	gold quality
muscle of leg	UBERON:0001383	76.61	gold quality
left adrenal gland cortex	UBERON:0035825	74.88	gold quality
ovary	UBERON:0000992	74.36	gold quality
left adrenal gland	UBERON:0001234	74.25	gold quality
stomach	UBERON:0000945	73.70	gold quality
lung	UBERON:0002048	72.82	gold quality
right adrenal gland	UBERON:0001233	72.51	gold quality
fallopian tube	UBERON:0003889	72.07	gold quality
gastrocnemius	UBERON:0001388	72.03	gold quality
body of pancreas	UBERON:0001150	71.98	gold quality
left uterine tube	UBERON:0001303	71.49	gold quality
islet of Langerhans	UBERON:0000006	71.03	gold quality
blood	UBERON:0000178	70.86	gold quality
body of stomach	UBERON:0001161	70.85	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.49	gold quality
vagina	UBERON:0000996	70.38	gold quality
right lobe of liver	UBERON:0001114	70.23	gold quality
gall bladder	UBERON:0002110	70.13	gold quality
adipose tissue	UBERON:0001013	70.01	gold quality
omental fat pad	UBERON:0010414	69.86	gold quality
heart left ventricle	UBERON:0002084	69.79	gold quality
endometrium	UBERON:0001295	69.66	gold quality
left lobe of thyroid gland	UBERON:0001120	69.18	gold quality
liver	UBERON:0002107	68.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.04

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Results found that miR-412 is highly expressed in hemorrhoid tissue. Its overexpression of miR-412 affects the function of vascular endothelial cells through activation of p53-p66SHC-p16 pathway. (PMID:31026569)
• Long non-coding RNA MBNL1-AS1 regulates proliferation, migration, and invasion of cancer stem cells in colon cancer by interacting with MYL9 via sponging microRNA-412-3p. (PMID:31255531)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir412	ENSMUSG00000065570
rattus_norvegicus	Mir412	ENSRNOG00000035490

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.