MIR423

Summary

MIR423 (microRNA 423, HGNC:31880) is a microRNA gene on chromosome 17q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 494335 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31880
Approved symbol	MIR423
Name	microRNA 423
Location	17q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-423
Ensembl gene	ENSG00000283935
Ensembl biotype	miRNA
Entrez	494335
RNAcentral	URS000075B951 — miRNA, 94 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362201

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362201 — 1 exons

Exon	Start	End
ENSE00003000033	30117079	30117172

Expression profiles

Bgee: expression breadth broad, 50 present calls, max score 78.16.

Top tissues by expression

50 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	78.16	gold quality
lung	UBERON:0002048	69.46	gold quality
gastrocnemius	UBERON:0001388	66.30	gold quality
liver	UBERON:0002107	66.10	gold quality
substantia nigra	UBERON:0002038	64.47	gold quality
left adrenal gland	UBERON:0001234	63.90	gold quality
heart left ventricle	UBERON:0002084	62.21	gold quality
body of pancreas	UBERON:0001150	61.26	gold quality
putamen	UBERON:0001874	60.89	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	59.70	gold quality
right atrium auricular region	UBERON:0006631	58.99	gold quality
lower esophagus muscularis layer	UBERON:0035833	58.28	gold quality
left ovary	UBERON:0002119	58.16	gold quality
transverse colon	UBERON:0001157	57.83	gold quality
subcutaneous adipose tissue	UBERON:0002190	57.47	gold quality
Ammon’s horn	UBERON:0001954	57.16	gold quality
spleen	UBERON:0002106	57.06	gold quality
esophagus mucosa	UBERON:0002469	56.78	gold quality
fundus of stomach	UBERON:0001160	56.68	gold quality
muscle layer of sigmoid colon	UBERON:0035805	56.52	gold quality
anterior cingulate cortex	UBERON:0009835	56.33	gold quality
left coronary artery	UBERON:0001626	55.88	gold quality
blood	UBERON:0000178	55.87	gold quality
skin of leg	UBERON:0001511	55.48	gold quality
thoracic mammary gland	UBERON:0005200	55.36	gold quality
tibial artery	UBERON:0007610	54.99	gold quality
skin of abdomen	UBERON:0001416	54.88	gold quality
body of stomach	UBERON:0001161	54.82	gold quality
ascending aorta	UBERON:0001496	54.27	gold quality
minor salivary gland	UBERON:0001830	54.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• Identify 6 miRNAs that are elevated in patients with heart failure (HF), among which miR423-5p is most strongly related to the clinical diagnosis of HF. (PMID:20185794)
• High MicroRNA-423 expression is associated with hepatocellular tumotigenesis by promoting cell growth and regulating G(1)/S transition by targeting p21Cip1/Waf1. (PMID:21890460)
• Circulating miR-423 is not a useful biomarker for heart failure when studied after atrial repair for transposition of the great arteries. (PMID:22188991)
• Research examined the effects of the rs6505162 SNP, an A > C polymorphism located in the pre-miRNA region of miR-423, on breast cancer development. (PMID:22593246)
• results demonstrate that plasma levels of selected miRNAs are potential biomarkers to differentiate localized PCa and mCRPC. (PMID:23574937)
• Early in acute myocardial infarction the expression of miR-423-5p in plasma is significantly increased with subsequent normalization within 6 hours (PMID:24253456)
• findings suggested that miR-423-5p may be a novel target for the future development of specific therapeutic interventions for gastric cancer (PMID:24486742)
• The difference in transcoronary gradients between heart failure outpatients and controls suggests that miR-423-5p has a cardiac origin. (PMID:24506564)
• Gene-environment interactions using MDR-pt program revealed that mir29a, mir34b, mir423 and Xpo5 modulated risk of disease (p < 0.002) which may be related to change in expression of these genes as observed by Real-Time PCR assays (PMID:24885463)
• miR-423-3p plays a novel oncogenic role in laryngeal cancer via AdipoR2 suppression. (PMID:25337209)
• these results suggest that the SNP rs6505162 in pre-miR-423 affects the mature miR expression, and miR-423 plays a potentially oncogenic role in breast tumorigenesis. (PMID:25663458)
• miR4235p was associated with congestive heart failure and the expression levels of proBNP; in addition, OGT was found to be a direct target of miR4235p. (PMID:25776937)
• detection of serum miR-484-5p and miR-484 may be useful for early diagnosis of colorectal cancer (PMID:25807655)
• present data suggest that rs6505162 C>A in pre-MIR423 may contribute to the genetic predisposition to recurrent miscarriage by disrupting the production of mature MIR423 and its target gene, which consequently interferes with MIR423 functioning. (PMID:25926693)
• Data showed that miR-423 was up-regulated in colorectal cancer (CRC) tissues promoting cell proliferation. Cip1 mediated the function of miR-423, and its overexpression reversed the augmented effect of miR-423 on cell proliferation. (PMID:26402653)
• miR-423-5p is enriched in pericardial fluid and serum and miR-423-5p may be associate with unstable angina pectoris. (PMID:26562412)
• This study supports the value of miR-423-5p as a prognostic biomarker of acute heart failure . (PMID:26580972)
• miR423-5p contributed to the tumorigenesis and progression of hepatocellular carcinoma. (PMID:26663009)
• This study showed the mir-423-5p significant enrichment in MuSK + MG patient sera. (PMID:26943954)
• Report detection of drug-induced acute kidney injury in humans by combining the sensitivity of urinary KIM-1 along with urinary miR-21, -200c, and -423. (PMID:27122240)
• High miR423 expression is associated with malignant phenotype and temozolomide chemoresistance in glioblastomas. (PMID:27471108)
• miR-423-3p activates oncogenic and Beclin-1-dependent autophagy and promotes GC progression by reducing the expression of Bim. The newly identified miR-423-3p-Bim axis might be a potential therapeutic target in GC. (PMID:28254439)
• indicates that downregulation of miR-423-5p enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway (PMID:28381178)
• under the obese condition, activation of the hepatic NFE2/miR-423-5p axis plays important roles in the progression of type 2 diabetes and NAFLD by repressing the FAM3A-ATP-Akt signaling pathway. (PMID:28411267)
• our results indicated that rs895819 was a protective factor for cancer in Caucasians and could increase colorectal cancer risk but decrease breast cancer risk. Moreover, rs6505162 was a protective factor for lung cancer. (PMID:28415619)
• Studies indicate that miR-423 rs6505162 single nucleotide polymorphism (SNP) might be associated with a reduced risk of cancers [Review; Meta-analysis] (PMID:28418884)
• analyses revealed an association between rs6505162 and Esophageal Squamous Cell Carcinoma, assuming codominant (AA vs. CC, odds ratios, OR [95% confidence interval, CI]: 0.32 [0.15-0.69], p-value: 0.0076), recessive (AA vs. CC+CA, OR [95% CI]: 0.35 [0.16-0.73], p-value: 0.0027), and log-additive models (OR[95% CI]: 0.69 [0.52-0.91], p-value: 0.0084). (PMID:28430524)
• aberrant plasma levels of these miRNAs are associated with the renal allograft dysfunction. Therefore, they are proposed to be considered as potential diagnostic biomarkers for monitoring of renal graft function. (PMID:28577875)
• MYC and hsamiR4235p have been identified to be critical biomarkers in nasopharyngeal carcinoma. (PMID:28586063)
• MIR423 contributes to training-induced bradycardia in athletes by targeting HCN4. (PMID:28821541)
• RFVT3 is a target for posttranscriptional regulation by miR-423-5p in intestinal epithelial cells, and this regulation has functional consequences on intestinal riboflavin (RF) uptake process. (PMID:28912250)
• Data suggest that MIR423 is potential biomarker candidate for early diagnosis of pre-eclampsia during targeted management of high-risk pregnancies; up-regulation of MIR423 expression occurs in placenta of women exhibiting severe pre-eclampsia at 28-33 weeks gestation; plasma levels of MIR423 are also up-regulated. (PMID:29277273)
• Expression levels of six reference microRNAs-hsa-miR-425-5p, hsa-miR-191-5p, hsa-miR-93-5p, hsa-miR-423-5p, hsa-miR-103a-3p, and hsa-miR-16-5p-were analyzed in plasma from vulvar intraepithelial neoplasia lesion and vulvar squamous cell carcinoma. (PMID:29299981)
• miR-423 rs6505162 C>A polymorphism was associated with the susceptibility and metastasis of Colorectal Carcinoma, and that miR-423 rs6505162 C>A polymorphism might be a potential biomarker for Colorectal Carcinoma. (PMID:29419695)
• MiR-423-5p enriched exosomes could be internalized into gastric cancer cells, which enhanced cell proliferation and migration both in vitro and in vivo. Mechanistically, miR-423-5p inhibited the expression of suppressor of fused protein (SUFU) to enhance the proliferation and migration of gastric cancer cells. (PMID:29749061)
• miR-423-5p overexpression protected high-glucose-induced podocyte damage by inhibiting ROS generation via targeting Nox4 (PMID:30245133)
• MicroRNA-423 Gene Variability is associated with Breast Cancer Progression. (PMID:30256064)
• Our findings indicated that microRNA-423 CA genotype and A allele are associated with an increased susceptibility to Coronary artery disease (PMID:30289085)
• Authors determined that AFAP1-AS1 functions as a competing endogenous RNA in NPC to regulate the Rho/Rac pathway through miR-423-5p. (PMID:30326930)
• MiR-423-5p inhibitor administration reduced tumor volume. (PMID:30415005)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.