MIR4252

Summary

MIR4252 (microRNA 4252, HGNC:38384) is a microRNA gene on chromosome 1p36.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422975 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38384
Approved symbol	MIR4252
Name	microRNA 4252
Location	1p36.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4252
Ensembl gene	ENSG00000265392
Ensembl biotype	miRNA
Entrez	100422975
RNAcentral	URS000075C378 — miRNA, 63 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585139

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585139 — 1 exons

Exon	Start	End
ENSE00002701441	6429834	6429896

Expression profiles

Bgee: expression breadth broad, 33 present calls, max score 80.19.

Top tissues by expression

33 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	80.19	gold quality
blood	UBERON:0000178	79.23	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	77.63	gold quality
monocyte	CL:0000576	75.63	gold quality
body of stomach	UBERON:0001161	74.39	gold quality
endometrium	UBERON:0001295	71.39	gold quality
adult mammalian kidney	UBERON:0000082	70.65	gold quality
subcutaneous adipose tissue	UBERON:0002190	69.94	gold quality
right frontal lobe	UBERON:0002810	69.60	gold quality
heart left ventricle	UBERON:0002084	69.19	gold quality
transverse colon	UBERON:0001157	68.86	gold quality
esophagus mucosa	UBERON:0002469	67.59	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.27	gold quality
zone of skin	UBERON:0000014	67.14	gold quality
skin of abdomen	UBERON:0001416	67.02	gold quality
skin of leg	UBERON:0001511	66.91	gold quality
left adrenal gland	UBERON:0001234	65.17	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.91	gold quality
spleen	UBERON:0002106	64.26	gold quality
adenohypophysis	UBERON:0002196	63.96	gold quality
fallopian tube	UBERON:0003889	63.78	gold quality
hypothalamus	UBERON:0001898	63.48	gold quality
vagina	UBERON:0000996	62.49	gold quality
cerebellar hemisphere	UBERON:0002245	62.14	gold quality
left ovary	UBERON:0002119	61.84	gold quality
upper lobe of left lung	UBERON:0008952	61.82	gold quality
pituitary gland	UBERON:0000007	61.32	gold quality
right uterine tube	UBERON:0001302	60.18	gold quality
thoracic mammary gland	UBERON:0005200	59.63	gold quality
colon	UBERON:0001155	58.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.50

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.