MIR4253

Summary

MIR4253 (microRNA 4253, HGNC:38231) is a microRNA gene on chromosome 1p36.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422914 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38231
Approved symbol	MIR4253
Name	microRNA 4253
Location	1p36.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4253
Ensembl gene	ENSG00000264014
Ensembl biotype	miRNA
Entrez	100422914
RNAcentral	URS000075A710 — miRNA, 68 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581187

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581187 — 1 exons

Exon	Start	End
ENSE00002690245	22863159	22863226

Expression profiles

Bgee: expression breadth broad, 39 present calls, max score 76.67.

Top tissues by expression

39 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stomach	UBERON:0000945	76.67	gold quality
adult mammalian kidney	UBERON:0000082	74.09	gold quality
right atrium auricular region	UBERON:0006631	68.79	gold quality
right frontal lobe	UBERON:0002810	67.88	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.70	gold quality
anterior cingulate cortex	UBERON:0009835	67.33	gold quality
omental fat pad	UBERON:0010414	66.85	gold quality
right lobe of thyroid gland	UBERON:0001119	66.44	gold quality
thoracic mammary gland	UBERON:0005200	66.01	gold quality
tibial artery	UBERON:0007610	65.94	gold quality
nucleus accumbens	UBERON:0001882	65.80	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.80	gold quality
left ovary	UBERON:0002119	65.61	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.60	gold quality
transverse colon	UBERON:0001157	65.57	gold quality
left coronary artery	UBERON:0001626	65.22	gold quality
colon	UBERON:0001155	64.80	gold quality
intestine	UBERON:0000160	64.73	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.21	gold quality
minor salivary gland	UBERON:0001830	64.01	gold quality
putamen	UBERON:0001874	63.87	gold quality
tibial nerve	UBERON:0001323	63.59	gold quality
skin of abdomen	UBERON:0001416	63.14	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.92	gold quality
esophagus mucosa	UBERON:0002469	62.70	gold quality
hypothalamus	UBERON:0001898	62.39	gold quality
subcutaneous adipose tissue	UBERON:0002190	62.24	gold quality
lung	UBERON:0002048	62.19	gold quality
lower esophagus muscularis layer	UBERON:0035833	61.86	gold quality
prostate gland	UBERON:0002367	61.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.09

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.