MIR4255

Summary

MIR4255 (microRNA 4255, HGNC:38187) is a microRNA gene on chromosome 1p34.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422898 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38187
Approved symbol	MIR4255
Name	microRNA 4255
Location	1p34.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4255
Ensembl gene	ENSG00000264698
Ensembl biotype	miRNA
Entrez	100422898
RNAcentral	URS000075C298 — ncRNA, 72 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579351

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579351 — 1 exons

Exon	Start	End
ENSE00002726111	37161563	37161634

Expression profiles

Bgee: expression breadth broad, 14 present calls, max score 75.12.

Top tissues by expression

14 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
dorsolateral prefrontal cortex	UBERON:0009834	75.12	gold quality
prostate gland	UBERON:0002367	72.33	gold quality
Brodmann (1909) area 9	UBERON:0013540	71.76	gold quality
monocyte	CL:0000576	71.20	gold quality
right frontal lobe	UBERON:0002810	67.27	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.18	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.04	gold quality
amygdala	UBERON:0001876	62.19	gold quality
tibial nerve	UBERON:0001323	62.00	gold quality
muscle layer of sigmoid colon	UBERON:0035805	61.89	gold quality
small intestine Peyer’s patch	UBERON:0003454	61.72	gold quality
caudate nucleus	UBERON:0001873	59.74	gold quality
corpus callosum	UBERON:0002336	56.66	gold quality
left testis	UBERON:0004533	43.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.