MIR4256

Summary

MIR4256 (microRNA 4256, HGNC:38388) is a microRNA gene on chromosome 1p13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422976 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38388
Approved symbol	MIR4256
Name	microRNA 4256
Location	1p13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4256
Ensembl gene	ENSG00000283296
Ensembl biotype	miRNA
Entrez	100422976
RNAcentral	URS000075B95C — miRNA, 64 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636356

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636356 — 1 exons

Exon	Start	End
ENSE00003795566	112461770	112461833

Expression profiles

Bgee: expression breadth broad, 93 present calls, max score 86.34.

Top tissues by expression

93 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	86.34	gold quality
adrenal tissue	UBERON:0018303	84.14	gold quality
calcaneal tendon	UBERON:0003701	79.82	gold quality
sural nerve	UBERON:0015488	77.59	gold quality
placenta	UBERON:0001987	77.56	gold quality
smooth muscle tissue	UBERON:0001135	77.24	gold quality
endometrium	UBERON:0001295	75.69	gold quality
muscle of leg	UBERON:0001383	75.45	gold quality
blood	UBERON:0000178	75.44	gold quality
monocyte	CL:0000576	74.32	gold quality
adrenal gland	UBERON:0002369	73.75	gold quality
gastrocnemius	UBERON:0001388	73.60	gold quality
stomach	UBERON:0000945	73.45	gold quality
lymph node	UBERON:0000029	73.35	gold quality
islet of Langerhans	UBERON:0000006	73.09	gold quality
heart left ventricle	UBERON:0002084	72.33	gold quality
heart	UBERON:0000948	72.06	gold quality
kidney	UBERON:0002113	71.98	gold quality
left adrenal gland cortex	UBERON:0035825	71.87	gold quality
adenohypophysis	UBERON:0002196	71.83	gold quality
body of pancreas	UBERON:0001150	71.00	gold quality
adult mammalian kidney	UBERON:0000082	70.85	gold quality
lung	UBERON:0002048	70.47	gold quality
intestine	UBERON:0000160	70.17	gold quality
left adrenal gland	UBERON:0001234	70.05	gold quality
tibial artery	UBERON:0007610	69.96	gold quality
colon	UBERON:0001155	69.91	gold quality
skin of leg	UBERON:0001511	69.75	gold quality
gall bladder	UBERON:0002110	69.55	gold quality
body of stomach	UBERON:0001161	69.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.45

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.