MIR4257

Summary

MIR4257 (microRNA 4257, HGNC:38312) is a microRNA gene on chromosome 1q21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422997 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38312
Approved symbol	MIR4257
Name	microRNA 4257
Location	1q21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4257
Ensembl gene	ENSG00000264553
Ensembl biotype	miRNA
Entrez	100422997
RNAcentral	URS000075D1D5 — miRNA, 86 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581735

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581735 — 1 exons

Exon	Start	End
ENSE00002690333	150551929	150552014

Expression profiles

Bgee: expression breadth ubiquitous, 117 present calls, max score 98.56.

Top tissues by expression

117 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	98.56	gold quality
granulocyte	CL:0000094	90.30	gold quality
right uterine tube	UBERON:0001302	88.98	gold quality
blood	UBERON:0000178	88.62	gold quality
vermiform appendix	UBERON:0001154	88.46	gold quality
left uterine tube	UBERON:0001303	87.50	gold quality
endometrium	UBERON:0001295	87.43	gold quality
skeletal muscle tissue	UBERON:0001134	86.71	gold quality
lower esophagus mucosa	UBERON:0035834	85.28	gold quality
mucosa of stomach	UBERON:0001199	84.07	gold quality
monocyte	CL:0000576	83.96	gold quality
saliva-secreting gland	UBERON:0001044	83.53	gold quality
placenta	UBERON:0001987	83.50	gold quality
leukocyte	CL:0000738	83.48	gold quality
minor salivary gland	UBERON:0001830	82.99	gold quality
right lung	UBERON:0002167	82.78	gold quality
body of uterus	UBERON:0009853	82.78	gold quality
esophagus mucosa	UBERON:0002469	82.58	gold quality
descending thoracic aorta	UBERON:0002345	82.51	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	82.10	gold quality
upper lobe of left lung	UBERON:0008952	81.70	gold quality
esophagus	UBERON:0001043	81.59	gold quality
lung	UBERON:0002048	81.45	gold quality
omental fat pad	UBERON:0010414	81.44	gold quality
thoracic aorta	UBERON:0001515	81.31	gold quality
ascending aorta	UBERON:0001496	81.28	gold quality
body of stomach	UBERON:0001161	81.17	gold quality
spleen	UBERON:0002106	81.06	gold quality
bone marrow	UBERON:0002371	80.96	gold quality
left coronary artery	UBERON:0001626	80.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.77

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The Role of Inflammation-associated microRNA-4257 as a Promoter of Malignancy in Colorectal Cancer. (PMID:35790263)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.