MIR4258

Summary

MIR4258 (microRNA 4258, HGNC:38281) is a microRNA gene on chromosome 1q21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423020 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38281
Approved symbol	MIR4258
Name	microRNA 4258
Location	1q21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4258
Ensembl gene	ENSG00000264349
Ensembl biotype	miRNA
Entrez	100423020
RNAcentral	URS000075E83C — ncRNA, 91 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580920

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580920 — 1 exons

Exon	Start	End
ENSE00002696234	154975693	154975783

Expression profiles

Bgee: expression breadth ubiquitous, 106 present calls, max score 84.29.

Top tissues by expression

106 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	84.29	gold quality
bone marrow	UBERON:0002371	84.05	gold quality
granulocyte	CL:0000094	81.94	gold quality
skeletal muscle tissue	UBERON:0001134	80.22	gold quality
vermiform appendix	UBERON:0001154	77.69	gold quality
endometrium	UBERON:0001295	77.62	gold quality
liver	UBERON:0002107	77.54	gold quality
right lobe of liver	UBERON:0001114	77.14	gold quality
lymph node	UBERON:0000029	76.70	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	76.12	gold quality
monocyte	CL:0000576	75.56	gold quality
placenta	UBERON:0001987	75.37	gold quality
body of stomach	UBERON:0001161	75.06	gold quality
stomach	UBERON:0000945	75.01	gold quality
blood	UBERON:0000178	74.41	gold quality
transverse colon	UBERON:0001157	74.01	gold quality
mucosa of transverse colon	UBERON:0004991	73.89	gold quality
fundus of stomach	UBERON:0001160	73.83	gold quality
islet of Langerhans	UBERON:0000006	73.73	gold quality
skin of abdomen	UBERON:0001416	73.59	gold quality
muscle of leg	UBERON:0001383	73.49	gold quality
right adrenal gland cortex	UBERON:0035827	73.44	gold quality
body of pancreas	UBERON:0001150	73.30	gold quality
small intestine	UBERON:0002108	73.15	gold quality
adrenal gland	UBERON:0002369	73.01	gold quality
rectum	UBERON:0001052	72.93	gold quality
right adrenal gland	UBERON:0001233	72.91	gold quality
left adrenal gland	UBERON:0001234	72.79	gold quality
intestine	UBERON:0000160	72.59	gold quality
zone of skin	UBERON:0000014	72.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.86

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.