MIR4259

Summary

MIR4259 (microRNA 4259, HGNC:38309) is a microRNA gene on chromosome 1q23.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422852 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38309
Approved symbol	MIR4259
Name	microRNA 4259
Location	1q23.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4259
Ensembl gene	ENSG00000266458
Ensembl biotype	miRNA
Entrez	100422852
RNAcentral	URS00007E3AE8 — miRNA, 101 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584466

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584466 — 1 exons

Exon	Start	End
ENSE00002704281	159899979	159900079

Expression profiles

Bgee: expression breadth broad, 36 present calls, max score 89.39.

Top tissues by expression

36 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	89.39	gold quality
sural nerve	UBERON:0015488	83.89	gold quality
blood	UBERON:0000178	77.59	gold quality
monocyte	CL:0000576	76.80	gold quality
islet of Langerhans	UBERON:0000006	73.56	gold quality
bone marrow	UBERON:0002371	72.65	gold quality
stomach	UBERON:0000945	71.73	gold quality
omental fat pad	UBERON:0010414	69.89	gold quality
lung	UBERON:0002048	68.79	gold quality
left lobe of thyroid gland	UBERON:0001120	68.27	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.19	gold quality
transverse colon	UBERON:0001157	67.95	gold quality
minor salivary gland	UBERON:0001830	67.83	gold quality
body of stomach	UBERON:0001161	67.65	gold quality
tibial artery	UBERON:0007610	66.80	gold quality
tibial nerve	UBERON:0001323	66.70	gold quality
upper lobe of left lung	UBERON:0008952	66.70	gold quality
esophagus mucosa	UBERON:0002469	66.45	gold quality
adipose tissue	UBERON:0001013	66.39	gold quality
ascending aorta	UBERON:0001496	66.23	gold quality
vagina	UBERON:0000996	66.04	gold quality
putamen	UBERON:0001874	66.03	gold quality
prostate gland	UBERON:0002367	66.00	gold quality
caudate nucleus	UBERON:0001873	65.98	gold quality
skin of abdomen	UBERON:0001416	65.83	gold quality
skin of leg	UBERON:0001511	65.41	gold quality
left ovary	UBERON:0002119	65.19	gold quality
right lobe of thyroid gland	UBERON:0001119	64.98	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.00	gold quality
cerebellar hemisphere	UBERON:0002245	62.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.