MIR4260

Summary

MIR4260 (microRNA 4260, HGNC:38179) is a microRNA gene on chromosome 1q32.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422894 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38179
Approved symbol	MIR4260
Name	microRNA 4260
Location	1q32.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4260
Ensembl gene	ENSG00000283876
Ensembl biotype	miRNA
Entrez	100422894
RNAcentral	URS000075D9BE — ncRNA, 67 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583107

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583107 — 1 exons

Exon	Start	End
ENSE00002723995	209623444	209623510

Expression profiles

Bgee: expression breadth broad, 62 present calls, max score 82.45.

Top tissues by expression

62 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	82.45	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	76.72	gold quality
blood	UBERON:0000178	75.99	gold quality
body of stomach	UBERON:0001161	75.80	gold quality
stomach	UBERON:0000945	75.77	gold quality
gall bladder	UBERON:0002110	74.55	gold quality
gastrocnemius	UBERON:0001388	73.00	gold quality
islet of Langerhans	UBERON:0000006	72.16	gold quality
heart left ventricle	UBERON:0002084	71.88	gold quality
urinary bladder	UBERON:0001255	71.40	gold quality
right lobe of thyroid gland	UBERON:0001119	71.00	gold quality
fundus of stomach	UBERON:0001160	70.39	gold quality
transverse colon	UBERON:0001157	70.32	gold quality
colon	UBERON:0001155	69.98	gold quality
lung	UBERON:0002048	69.45	gold quality
endometrium	UBERON:0001295	69.27	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.20	gold quality
upper lobe of left lung	UBERON:0008952	69.18	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.13	gold quality
esophagus mucosa	UBERON:0002469	68.78	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.63	gold quality
right adrenal gland	UBERON:0001233	68.44	gold quality
vagina	UBERON:0000996	68.39	gold quality
small intestine Peyer’s patch	UBERON:0003454	68.12	gold quality
minor salivary gland	UBERON:0001830	67.75	gold quality
skin of abdomen	UBERON:0001416	67.72	gold quality
omental fat pad	UBERON:0010414	67.57	gold quality
left coronary artery	UBERON:0001626	67.14	gold quality
substantia nigra	UBERON:0002038	67.03	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.71	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.56

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Significantly, miR-4260 was increased in human colorectal cancer tissues with simultaneous downregulation of MCC and SMAD4. (PMID:28638476)
• Variants in miRNA regulome and their association with the risk of nonsyndromic orofacial clefts. (PMID:32408759)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.