MIR4261

Summary

MIR4261 (microRNA 4261, HGNC:38272) is a microRNA gene on chromosome 2p25.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422929 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38272
Approved symbol	MIR4261
Name	microRNA 4261
Location	2p25.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4261
Ensembl gene	ENSG00000265418
Ensembl biotype	miRNA
Entrez	100422929
RNAcentral	URS000075BFB5 — ncRNA, 58 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580325

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580325 — 1 exons

Exon	Start	End
ENSE00002703664	10192614	10192671

Expression profiles

Bgee: expression breadth broad, 47 present calls, max score 81.72.

Top tissues by expression

47 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	81.72	gold quality
bone marrow	UBERON:0002371	81.31	gold quality
monocyte	CL:0000576	78.25	gold quality
heart	UBERON:0000948	77.64	gold quality
placenta	UBERON:0001987	77.20	gold quality
left adrenal gland cortex	UBERON:0035825	75.27	gold quality
adrenal tissue	UBERON:0018303	75.21	gold quality
blood	UBERON:0000178	74.03	gold quality
rectum	UBERON:0001052	73.03	gold quality
gastrocnemius	UBERON:0001388	72.74	gold quality
right atrium auricular region	UBERON:0006631	72.58	gold quality
liver	UBERON:0002107	71.74	gold quality
left adrenal gland	UBERON:0001234	71.13	gold quality
body of pancreas	UBERON:0001150	69.86	gold quality
ascending aorta	UBERON:0001496	69.60	gold quality
stomach	UBERON:0000945	69.42	gold quality
tibial artery	UBERON:0007610	69.25	gold quality
heart left ventricle	UBERON:0002084	69.10	gold quality
lung	UBERON:0002048	69.06	gold quality
esophagus mucosa	UBERON:0002469	68.12	gold quality
endometrium	UBERON:0001295	68.06	gold quality
transverse colon	UBERON:0001157	67.92	gold quality
omental fat pad	UBERON:0010414	67.88	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.84	gold quality
colon	UBERON:0001155	67.61	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.22	gold quality
ectocervix	UBERON:0012249	67.00	gold quality
intestine	UBERON:0000160	66.96	gold quality
skin of abdomen	UBERON:0001416	66.88	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.14

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• the critical role of MEG3-miR-4261-DKK2-Wnt/beta-catenin signalling axis in ESCC (PMID:30990378)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.