MIR4262

Summary

MIR4262 (microRNA 4262, HGNC:38308) is a microRNA gene on chromosome 2p25.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422996 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38308
Approved symbol	MIR4262
Name	microRNA 4262
Location	2p25.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4262
Ensembl gene	ENSG00000265172
Ensembl biotype	miRNA
Entrez	100422996
RNAcentral	URS000075BACE — miRNA, 54 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578394

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578394 — 1 exons

Exon	Start	End
ENSE00002713694	11836933	11836986

Expression profiles

Bgee: expression breadth broad, 30 present calls, max score 77.22.

Top tissues by expression

30 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	77.22	gold quality
gastrocnemius	UBERON:0001388	75.84	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	73.43	gold quality
esophagus mucosa	UBERON:0002469	72.89	gold quality
lung	UBERON:0002048	71.14	gold quality
liver	UBERON:0002107	70.78	gold quality
esophagus	UBERON:0001043	70.25	gold quality
tibial artery	UBERON:0007610	69.87	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.35	gold quality
transverse colon	UBERON:0001157	69.08	gold quality
right frontal lobe	UBERON:0002810	68.94	gold quality
omental fat pad	UBERON:0010414	68.73	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.59	gold quality
body of stomach	UBERON:0001161	67.90	gold quality
caudate nucleus	UBERON:0001873	67.50	gold quality
left ovary	UBERON:0002119	67.36	gold quality
small intestine Peyer’s patch	UBERON:0003454	65.11	gold quality
tibial nerve	UBERON:0001323	64.65	gold quality
skin of leg	UBERON:0001511	64.54	gold quality
upper lobe of left lung	UBERON:0008952	64.39	gold quality
spleen	UBERON:0002106	64.30	gold quality
hypothalamus	UBERON:0001898	63.95	gold quality
right hemisphere of cerebellum	UBERON:0014890	63.67	gold quality
cerebellar hemisphere	UBERON:0002245	63.44	gold quality
thoracic mammary gland	UBERON:0005200	62.55	gold quality
colon	UBERON:0001155	59.61	gold quality
endometrium	UBERON:0001295	58.78	gold quality
testis	UBERON:0000473	49.55	gold quality
left testis	UBERON:0004533	49.44	gold quality
right testis	UBERON:0004534	47.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.38

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 11)

• miR-4262 suppresses OS metastases through OPN inhibition. Downregulation of miR-4262 appears to directly contribute to the distal metastases of primary OS and subsequently poor prognosis. (PMID:26634745)
• miR-4262 may play a role in the development of hepatocellular carcinoma (PMID:26778158)
• MIR-4262 positively regulates proliferation and invasion of breast cancer cells by suppressing KLF6 and KLF15. (PMID:27629257)
• KLF6 acts as a tumor suppressor in CMM cells and miR-4262 promotes the proliferation of CMM cells through KLF6-mediated EGFR inactivation and p21 upregulation. (PMID:27779691)
• miR4262 may be involved in the development of colon cancer via targeting of GALNT4. (PMID:28731150)
• The level of miR-4262 was found to be significantly decreased in CC tissues and cell lines. Moreover, decreased expression of miR-4262 was closely related to increased expression of Kaiso (ZBTB33). (PMID:28800784)
• Silence of MEG3 intensifies lipopolysaccharide-stimulated damage of human lung cells through modulating miR-4262 (PMID:31184231)
• Abnormal increase of miR-4262 promotes cell proliferation and migration by targeting large tumor suppressor 1 in gliomas. (PMID:31831299)
• MiR-4262 inhibits the development of esophageal cancer by negatively regulating KLF6 level. (PMID:32473153)
• Long noncoding RNA LIFR-AS1 suppresses proliferation, migration and invasion and promotes apoptosis through modulating miR-4262/NF-kappaB pathway in glioma. (PMID:33070767)
• Salidroside suppresses the activation of nasopharyngeal carcinoma cells via targeting miR-4262/GRP78 axis. (PMID:35220889)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.