MIR4263

Summary

MIR4263 (microRNA 4263, HGNC:38365) is a microRNA gene on chromosome 2p23.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422965 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38365
Approved symbol	MIR4263
Name	microRNA 4263
Location	2p23.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4263
Ensembl gene	ENSG00000265321
Ensembl biotype	miRNA
Entrez	100422965
RNAcentral	URS000075E72B — ncRNA, 83 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584745

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584745 — 1 exons

Exon	Start	End
ENSE00002707329	27996367	27996449

Expression profiles

Bgee: expression breadth ubiquitous, 110 present calls, max score 98.22.

Top tissues by expression

110 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	98.22	gold quality
right adrenal gland	UBERON:0001233	89.86	gold quality
left adrenal gland	UBERON:0001234	89.00	gold quality
adrenal gland	UBERON:0002369	87.88	gold quality
left adrenal gland cortex	UBERON:0035825	87.82	gold quality
right adrenal gland cortex	UBERON:0035827	86.94	gold quality
endometrium	UBERON:0001295	85.52	gold quality
rectum	UBERON:0001052	85.26	gold quality
vermiform appendix	UBERON:0001154	84.32	gold quality
duodenum	UBERON:0002114	83.76	gold quality
monocyte	CL:0000576	83.61	gold quality
bone marrow	UBERON:0002371	83.18	gold quality
lower esophagus mucosa	UBERON:0035834	82.38	gold quality
placenta	UBERON:0001987	81.06	gold quality
fallopian tube	UBERON:0003889	80.60	gold quality
lymph node	UBERON:0000029	80.11	gold quality
right uterine tube	UBERON:0001302	79.94	gold quality
islet of Langerhans	UBERON:0000006	79.83	gold quality
adult mammalian kidney	UBERON:0000082	79.64	gold quality
tonsil	UBERON:0002372	79.63	gold quality
liver	UBERON:0002107	78.90	gold quality
granulocyte	CL:0000094	78.89	gold quality
kidney	UBERON:0002113	78.65	gold quality
blood	UBERON:0000178	78.47	gold quality
adrenal tissue	UBERON:0018303	78.32	gold quality
smooth muscle tissue	UBERON:0001135	77.76	gold quality
right lobe of liver	UBERON:0001114	77.07	gold quality
esophagus mucosa	UBERON:0002469	76.58	gold quality
gall bladder	UBERON:0002110	75.28	gold quality
body of pancreas	UBERON:0001150	74.85	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.77

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.