MIR4264

Summary

MIR4264 (microRNA 4264, HGNC:38338) is a microRNA gene on chromosome 2p12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422888 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38338
Approved symbol	MIR4264
Name	microRNA 4264
Location	2p12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4264
Ensembl gene	ENSG00000266436
Ensembl biotype	miRNA
Entrez	100422888
RNAcentral	URS000075E236 — miRNA, 66 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583520

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583520 — 1 exons

Exon	Start	End
ENSE00002717763	79649294	79649359

Expression profiles

Bgee: expression breadth broad, 21 present calls, max score 75.61.

Top tissues by expression

21 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	75.61	gold quality
Ammon’s horn	UBERON:0001954	70.43	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.75	gold quality
left lobe of thyroid gland	UBERON:0001120	68.67	gold quality
cerebellar hemisphere	UBERON:0002245	67.22	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.77	gold quality
body of pancreas	UBERON:0001150	66.09	gold quality
endometrium	UBERON:0001295	65.58	gold quality
intestine	UBERON:0000160	64.23	gold quality
nucleus accumbens	UBERON:0001882	64.05	gold quality
right frontal lobe	UBERON:0002810	63.48	gold quality
putamen	UBERON:0001874	63.26	gold quality
tibial nerve	UBERON:0001323	61.95	gold quality
anterior cingulate cortex	UBERON:0009835	58.68	gold quality
corpus callosum	UBERON:0002336	55.34	gold quality
caudate nucleus	UBERON:0001873	54.74	gold quality
colon	UBERON:0001155	54.40	gold quality
stomach	UBERON:0000945	49.65	gold quality
left testis	UBERON:0004533	46.07	gold quality
right testis	UBERON:0004534	45.41	gold quality
hypothalamus	UBERON:0001898	40.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.