MIR4265

Summary

MIR4265 (microRNA 4265, HGNC:38358) is a microRNA gene on chromosome 2q13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422863 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38358
Approved symbol	MIR4265
Name	microRNA 4265
Location	2q13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4265
Ensembl gene	ENSG00000264934
Ensembl biotype	miRNA
Entrez	100422863
RNAcentral	URS000075D8B9 — ncRNA, 99 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582152

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582152 — 1 exons

Exon	Start	End
ENSE00002709605	109141490	109141588

Expression profiles

Bgee: expression breadth broad, 73 present calls, max score 93.22.

Top tissues by expression

73 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	93.22	gold quality
corpus callosum	UBERON:0002336	89.16	gold quality
liver	UBERON:0002107	83.82	gold quality
blood	UBERON:0000178	80.59	gold quality
bone marrow	UBERON:0002371	79.50	gold quality
calcaneal tendon	UBERON:0003701	77.03	gold quality
gastrocnemius	UBERON:0001388	76.34	gold quality
monocyte	CL:0000576	75.03	gold quality
stomach	UBERON:0000945	74.86	gold quality
myometrium	UBERON:0001296	73.72	gold quality
adrenal tissue	UBERON:0018303	72.44	gold quality
body of pancreas	UBERON:0001150	72.30	gold quality
tibial artery	UBERON:0007610	70.63	gold quality
popliteal artery	UBERON:0002250	70.41	gold quality
heart	UBERON:0000948	69.26	gold quality
right atrium auricular region	UBERON:0006631	69.26	gold quality
body of stomach	UBERON:0001161	69.25	gold quality
endometrium	UBERON:0001295	69.22	gold quality
ascending aorta	UBERON:0001496	68.89	gold quality
descending thoracic aorta	UBERON:0002345	68.79	gold quality
thoracic aorta	UBERON:0001515	68.76	gold quality
left adrenal gland cortex	UBERON:0035825	68.76	gold quality
colon	UBERON:0001155	68.58	gold quality
body of uterus	UBERON:0009853	68.15	gold quality
left adrenal gland	UBERON:0001234	68.06	gold quality
intestine	UBERON:0000160	67.96	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.87	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.69	gold quality
transverse colon	UBERON:0001157	67.59	gold quality
omental fat pad	UBERON:0010414	67.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.34

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.