MIR4266

Summary

MIR4266 (microRNA 4266, HGNC:38175) is a microRNA gene on chromosome 2q13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423027 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38175
Approved symbol	MIR4266
Name	microRNA 4266
Location	2q13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4266
Ensembl gene	ENSG00000265965
Ensembl biotype	miRNA
Entrez	100423027
RNAcentral	URS000075D9BA — ncRNA, 55 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583300

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583300 — 1 exons

Exon	Start	End
ENSE00002699377	109313571	109313625

Expression profiles

Bgee: expression breadth broad, 46 present calls, max score 80.19.

Top tissues by expression

46 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	80.19	gold quality
calcaneal tendon	UBERON:0003701	78.90	gold quality
liver	UBERON:0002107	76.61	gold quality
prefrontal cortex	UBERON:0000451	76.49	gold quality
gastrocnemius	UBERON:0001388	74.41	gold quality
adult mammalian kidney	UBERON:0000082	73.69	gold quality
monocyte	CL:0000576	72.59	gold quality
tibial nerve	UBERON:0001323	72.32	gold quality
rectum	UBERON:0001052	72.25	gold quality
heart left ventricle	UBERON:0002084	71.46	gold quality
stomach	UBERON:0000945	71.39	gold quality
heart	UBERON:0000948	71.12	gold quality
corpus callosum	UBERON:0002336	70.65	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.69	gold quality
omental fat pad	UBERON:0010414	69.26	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.11	gold quality
skin of leg	UBERON:0001511	68.85	gold quality
anterior cingulate cortex	UBERON:0009835	68.83	gold quality
popliteal artery	UBERON:0002250	68.79	gold quality
substantia nigra	UBERON:0002038	68.77	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.72	gold quality
tibial artery	UBERON:0007610	68.47	gold quality
ascending aorta	UBERON:0001496	68.19	gold quality
amygdala	UBERON:0001876	67.94	gold quality
right atrium auricular region	UBERON:0006631	67.51	gold quality
right frontal lobe	UBERON:0002810	66.92	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.69	gold quality
nucleus accumbens	UBERON:0001882	66.48	gold quality
left ovary	UBERON:0002119	66.23	gold quality
skin of abdomen	UBERON:0001416	65.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.