MIR4268

Summary

MIR4268 (microRNA 4268, HGNC:38352) is a microRNA gene on chromosome 2q35.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422959 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38352
Approved symbol	MIR4268
Name	microRNA 4268
Location	2q35
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4268
Ensembl gene	ENSG00000266518
Ensembl biotype	miRNA
Entrez	100422959
RNAcentral	URS000075A41B — miRNA, 64 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581624

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581624 — 1 exons

Exon	Start	End
ENSE00002694029	219906502	219906565

Expression profiles

Bgee: expression breadth tissue_specific, 7 present calls, max score 77.21.

Top tissues by expression

7 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	77.21	gold quality
putamen	UBERON:0001874	74.99	gold quality
heart	UBERON:0000948	71.31	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.35	gold quality
caudate nucleus	UBERON:0001873	63.60	gold quality
testis	UBERON:0000473	45.90	gold quality
left testis	UBERON:0004533	44.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MiR-4268 suppresses gastric cancer genesis through inhibiting keratin 80. (PMID:35748914)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.