MIR4269

Summary

MIR4269 (microRNA 4269, HGNC:38291) is a microRNA gene on chromosome 2q37.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423043 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38291
Approved symbol	MIR4269
Name	microRNA 4269
Location	2q37.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4269
Ensembl gene	ENSG00000265215
Ensembl biotype	miRNA
Entrez	100423043
RNAcentral	URS000075D0CE — miRNA, 84 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578705

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578705 — 1 exons

Exon	Start	End
ENSE00002704176	239305462	239305545

Expression profiles

Bgee: expression breadth ubiquitous, 103 present calls, max score 91.86.

Top tissues by expression

103 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	91.86	gold quality
muscle of leg	UBERON:0001383	91.11	gold quality
gastrocnemius	UBERON:0001388	90.94	gold quality
adrenal tissue	UBERON:0018303	85.49	gold quality
endocervix	UBERON:0000458	82.15	gold quality
ectocervix	UBERON:0012249	82.00	gold quality
blood	UBERON:0000178	81.94	gold quality
prefrontal cortex	UBERON:0000451	79.58	gold quality
calcaneal tendon	UBERON:0003701	79.39	gold quality
muscle layer of sigmoid colon	UBERON:0035805	79.10	gold quality
monocyte	CL:0000576	78.59	gold quality
stomach	UBERON:0000945	78.25	gold quality
lower esophagus	UBERON:0013473	78.15	gold quality
lower esophagus muscularis layer	UBERON:0035833	78.10	gold quality
urinary bladder	UBERON:0001255	78.09	gold quality
corpus callosum	UBERON:0002336	77.79	gold quality
Brodmann (1909) area 9	UBERON:0013540	77.36	gold quality
colon	UBERON:0001155	77.13	gold quality
placenta	UBERON:0001987	76.71	gold quality
body of stomach	UBERON:0001161	76.64	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	76.62	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	76.54	gold quality
intestine	UBERON:0000160	76.32	gold quality
endometrium	UBERON:0001295	75.89	gold quality
frontal cortex	UBERON:0001870	75.30	gold quality
right frontal lobe	UBERON:0002810	74.84	gold quality
cerebral cortex	UBERON:0000956	74.81	gold quality
esophagus	UBERON:0001043	74.15	gold quality
heart left ventricle	UBERON:0002084	73.93	gold quality
right adrenal gland	UBERON:0001233	73.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• TEAD1 and TEAD4 are oncogenic factors, whose aberrant activation are, in part, mediated by the silence of miR-377-3p, miR-1343-3p and miR-4269. (PMID:28759040)
• MiR-4269 suppresses the tumorigenesis and development of pancreatic cancer by targeting ZEB1/OTX1 pathway. (PMID:32484209)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.