MIR4270

Summary

MIR4270 (microRNA 4270, HGNC:38377) is a microRNA gene on chromosome 3p25.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422868 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38377
Approved symbol	MIR4270
Name	microRNA 4270
Location	3p25.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4270
Ensembl gene	ENSG00000263573
Ensembl biotype	miRNA
Entrez	100422868
RNAcentral	URS000075D4C1 — miRNA, 70 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581799

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581799 — 1 exons

Exon	Start	End
ENSE00002717760	15496239	15496308

Expression profiles

Bgee: expression breadth broad, 34 present calls, max score 75.95.

Top tissues by expression

34 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	75.95	gold quality
body of stomach	UBERON:0001161	74.91	gold quality
gastrocnemius	UBERON:0001388	73.62	gold quality
substantia nigra	UBERON:0002038	73.11	gold quality
adrenal gland	UBERON:0002369	69.38	gold quality
thyroid gland	UBERON:0002046	69.21	gold quality
heart left ventricle	UBERON:0002084	69.00	gold quality
heart	UBERON:0000948	68.86	gold quality
tibial artery	UBERON:0007610	68.75	gold quality
stomach	UBERON:0000945	67.88	gold quality
transverse colon	UBERON:0001157	67.87	gold quality
Ammon’s horn	UBERON:0001954	67.80	gold quality
right atrium auricular region	UBERON:0006631	67.15	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.79	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.32	gold quality
amygdala	UBERON:0001876	65.88	gold quality
ascending aorta	UBERON:0001496	65.14	gold quality
endometrium	UBERON:0001295	64.79	gold quality
skin of leg	UBERON:0001511	64.50	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.48	gold quality
skin of abdomen	UBERON:0001416	64.37	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.92	gold quality
omental fat pad	UBERON:0010414	63.91	gold quality
putamen	UBERON:0001874	63.27	gold quality
cerebellar hemisphere	UBERON:0002245	61.42	gold quality
caudate nucleus	UBERON:0001873	61.27	gold quality
spleen	UBERON:0002106	61.09	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	61.05	gold quality
right hemisphere of cerebellum	UBERON:0014890	61.04	gold quality
pituitary gland	UBERON:0000007	59.99	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.08

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• microRNA-4270-5p inhibits cancer cell proliferation and metastasis in hepatocellular carcinoma by targeting SATB2. (PMID:32504285)
• Urinary miR-3137 and miR-4270 as potential biomarkers for diabetic kidney disease. (PMID:32869917)
• miR-4270 Modulates the Irradiation-Sensitivity of Nasopharyngeal Carcinoma Cells through Modulation of p53 in Vivo. (PMID:34078755)
• Effect of miR-4270 Suppression on Migration in Hepatocellular Carcinoma Cell Line (HepG2). (PMID:37430248)
• miR-4270 suppresses hepatocellular carcinoma progression by inhibiting DNMT3A-mediated methylation of HGFAC promoter. (PMID:38077422)
• The Association between the Expression of MicroRNA-4270 and MicroRNA-4441 with some Metabolic Factors in Iranian Rheumatoid Arthritis Patients. (PMID:38477951)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.